{"id":"W2117838862","doi":"10.18433/j3z312","title":"Long-term Stable Cationic Solid Lipid Nanoparticles for the Enhanced Intracellular Delivery of SMAD3 Antisense Oligonucleotides in Activated Murine Macrophages","year":2012,"lang":"en","type":"article","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Flow cytometry; Intracellular; Chemistry; Cationic liposome; Oligonucleotide; Zeta potential; Macrophage; Cationic polymerization; Blot; Cytotoxicity; Biophysics; Molecular biology; Biochemistry; Nanoparticle; Materials science; In vitro; Transfection; Biology; Nanotechnology; DNA; Polymer chemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001756593,0.0003011091,0.0001594783,0.0001480264,0.0001040815,0.00016265,0.0001163713,0.0003104651,0.0003961314],"category_scores_gemma":[0.0001043274,0.0001008081,0.0002367883,0.00008573298,0.0001832559,0.0002049229,0.000187381,0.0002830696,0.0001859327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002901564,"about_ca_system_score_gemma":0.0002095364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002638534,"about_ca_topic_score_gemma":0.0005566666,"domain_scores_codex":[0.9999045,0.00001576151,0.00000769903,0.00002054818,0.00003395235,0.00001745587],"domain_scores_gemma":[0.9999397,0.00000697803,0.00002271764,0.000003999788,0.00001600379,0.00001062726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003886989,0.000008135404,0.00003455989,0.00003278734,0.000002206634,0.00001683186,0.000006115159,0.00008009288,0.9989305,0.00003952755,0.00001564239,0.0007946789],"study_design_scores_gemma":[0.00001215662,0.0001823951,0.0002329559,0.000003851974,0.000009929592,0.00006153603,0.000007489876,0.0006748714,0.9975653,0.00001727087,0.00122861,0.000003759285],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9762635,0.003217804,0.01880193,0.0001563362,0.0000700036,0.00007785573,0.0001485268,0.0001143717,0.001149729],"genre_scores_gemma":[0.9828703,0.001557776,0.01237114,0.00008488965,0.00001860612,0.0001199546,0.0001603273,0.00002772127,0.002789316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003961314,"threshold_uncertainty_score":0.002105236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0461503020983946,"score_gpt":0.3670367038202126,"score_spread":0.320886401721818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}