{"id":"W2117847026","doi":"10.15252/emmm.201404402","title":"Combined deletion of Pten and p53 in mammary epithelium accelerates triple‐negative breast cancer with dependency on eEF2K","year":2014,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Lunenfeld-Tanenbaum Research Institute; Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto; University Health Network","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; Terry Fox Foundation; Government of Ontario","keywords":"PTEN; Cancer research; Kinome; PI3K/AKT/mTOR pathway; Triple-negative breast cancer; Protein kinase B; Biology; Gene silencing; Breast cancer; Cancer; Signal transduction; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003852302,0.0003279841,0.0007456563,0.0003999636,0.0000390661,0.000007626803,0.0001354148,0.0001726768,0.0001234127],"category_scores_gemma":[0.0002108114,0.0002453192,0.00005847562,0.0005702307,0.0002427775,0.00007249743,0.00005022282,0.0004348533,0.00000440772],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001356384,"about_ca_system_score_gemma":0.0001751527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008779854,"about_ca_topic_score_gemma":0.0001651345,"domain_scores_codex":[0.9978996,0.0001668048,0.0004710574,0.0005138859,0.0006040099,0.000344658],"domain_scores_gemma":[0.9987231,0.00009199339,0.0002213319,0.0004850989,0.0002544613,0.0002240148],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.007979138,0.0008650682,0.0160596,0.0008869711,0.0007689068,0.001179389,0.00224144,0.0004311726,0.8779705,0.006242788,0.0009525371,0.08442246],"study_design_scores_gemma":[0.06835108,0.01213149,0.4940014,0.009626002,0.001136088,0.001048634,0.0006190971,0.00830589,0.3996308,0.003232125,0.0006362161,0.001281183],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.975914,0.001701614,0.00621101,0.01010124,0.0002151205,0.001156544,0.00002160928,0.00007328405,0.004605589],"genre_scores_gemma":[0.9969787,0.0004563984,0.0004883456,0.001675792,0.0001003636,0.00008280838,0.00004728568,0.00006010523,0.0001102305],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4783398,"threshold_uncertainty_score":0.9999999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00792320138581221,"score_gpt":0.2459366295252566,"score_spread":0.2380134281394444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}