{"id":"W2117847026","doi":"10.15252/emmm.201404402","title":"Combined deletion of Pten and p53 in mammary epithelium accelerates triple‐negative breast cancer with dependency on eEF2K","year":2014,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Lunenfeld-Tanenbaum Research Institute; Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto; University Health Network","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; Terry Fox Foundation; Government of Ontario","keywords":"PTEN; Cancer research; Kinome; PI3K/AKT/mTOR pathway; Triple-negative breast cancer; Protein kinase B; Biology; Gene silencing; Breast cancer; Cancer; Signal transduction; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000113787,0.0003126915,0.0002313981,0.0002628859,0.0001420686,0.0002866337,0.0001275031,0.0001490973,0.0006742149],"category_scores_gemma":[0.00009682145,0.0001370963,0.0001948897,0.0001522427,0.0001866996,0.0001342685,0.0002067879,0.0003588514,0.0001744299],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002894359,"about_ca_system_score_gemma":0.0002178086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005556687,"about_ca_topic_score_gemma":0.001314178,"domain_scores_codex":[0.9998758,0.00001368611,0.00001035743,0.0000191673,0.00004640727,0.0000346672],"domain_scores_gemma":[0.9999269,0.0000107706,0.0000239627,0.000006883996,0.000005278319,0.00002624232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001391207,0.00002186006,0.0004908924,0.00001144158,0.000005818577,0.00006793338,0.000004815221,0.00005614506,0.9982526,0.00003406348,0.00002147434,0.0008938839],"study_design_scores_gemma":[0.00001345906,0.0003817128,0.01142414,0.000002573581,0.00002319668,0.0006576494,0.00001635997,0.0007672125,0.9852569,0.0000270281,0.001426473,0.000003384148],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979627,0.0006387066,0.0006404123,0.00004610962,0.000009198989,0.00001052342,0.0001251838,0.00005145867,0.0005157949],"genre_scores_gemma":[0.9979758,0.0003892333,0.0004653301,0.00001729913,0.000002300437,0.00001247618,0.0002097587,0.000008091149,0.0009197737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006742149,"threshold_uncertainty_score":0.002255499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00792320138581221,"score_gpt":0.2459366295252566,"score_spread":0.2380134281394444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}