{"id":"W2117857469","doi":"10.1161/circresaha.108.171157","title":"Mechanisms Underlying Rate-Dependent Remodeling of Transient Outward Potassium Current in Canine Ventricular Myocytes","year":2008,"lang":"en","type":"article","venue":"Circulation Research","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Phospholamban; Calcineurin; Downregulation and upregulation; NFAT; Endocrinology; Myocyte; Internal medicine; Calmodulin; Chemistry; GTPgammaS; Cardiac transient outward potassium current; Patch clamp; Sodium-calcium exchanger; Cell biology; Calcium; Biology; Electrophysiology; Medicine; Biochemistry; G protein; Transplantation; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009999817,0.0001091865,0.0003188908,0.0004559673,0.0001482293,0.000006093345,0.0000658501,0.0001045554,0.00005055533],"category_scores_gemma":[0.0001819524,0.0001035354,0.0001258617,0.0005918134,0.00009394576,0.00006455906,0.00003015097,0.0005615153,0.00001925058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002509594,"about_ca_system_score_gemma":0.0003137143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001447751,"about_ca_topic_score_gemma":0.00001338161,"domain_scores_codex":[0.9979934,0.0003167069,0.0003604253,0.0003157526,0.0006108187,0.0004028753],"domain_scores_gemma":[0.9991059,0.0001344421,0.00005417412,0.0002560843,0.000342743,0.000106687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007441133,0.0005455489,0.0140984,0.0004212722,0.0001172405,0.00163804,0.001585748,0.2466809,0.7227244,0.002072064,0.0001449332,0.009227407],"study_design_scores_gemma":[0.004259953,0.0004369313,0.8632752,0.0004292048,0.00006358181,0.000636261,0.0004136313,0.1050208,0.02142562,0.003623984,0.00009247222,0.0003223606],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988952,0.001343335,0.008413871,0.0004151069,0.0001286435,0.0005251935,0.000003314895,0.00002501797,0.0001935258],"genre_scores_gemma":[0.9993886,0.0002886779,0.0001221881,0.00002357543,0.0000507419,0.00002857374,0.00003985321,0.00001765648,0.00004008762],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8491768,"threshold_uncertainty_score":0.4222052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1330342263668625,"score_gpt":0.3809984893338462,"score_spread":0.2479642629669837,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}