{"id":"W2117858538","doi":"10.15252/embr.201540081","title":"Wnt directs the endosomal flux of LDL‐derived cholesterol and lipid droplet homeostasis","year":2015,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Center of Competence in Research Chemical Biology; Swiss Institute of Bioinformatics; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Endosome; Wnt signaling pathway; Cell biology; Endocytosis; Flux (metallurgy); LRP5; Lipid droplet; WNT3A; Biology; Lipid metabolism; Frizzled; Homeostasis; LRP6; Chemistry; Signal transduction; Biochemistry; Cell; Intracellular","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002443284,0.0001176781,0.0001505092,0.00002126858,0.00004289606,0.00001542352,0.00006142919,0.00009636165,0.00001590309],"category_scores_gemma":[0.00004896635,0.00008820046,0.00006887312,0.000048252,0.00009451614,0.000004063747,0.00003582934,0.00005875014,0.000001345001],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005681817,"about_ca_system_score_gemma":0.00005768991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005878484,"about_ca_topic_score_gemma":0.00006314763,"domain_scores_codex":[0.9991481,0.00003701317,0.0002547357,0.0002553286,0.0001589064,0.0001458655],"domain_scores_gemma":[0.9993361,0.000005272198,0.0001451622,0.0003412857,0.00007734401,0.0000948297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003894722,0.00003578587,0.02101029,0.00001709856,0.00003823647,0.00005379866,0.0002454699,0.000007490138,0.9765091,0.000008900896,0.0001918689,0.001843012],"study_design_scores_gemma":[0.000471419,0.0002296697,0.04670181,0.0000177108,0.00005246211,0.0003562873,0.0001513194,0.0000118359,0.864729,0.00007696115,0.08702426,0.0001772336],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965497,0.001171728,0.0004737986,0.0001431511,0.0002338066,0.0001632364,0.000005312103,0.00001041555,0.001248838],"genre_scores_gemma":[0.9983256,0.0001175937,0.00006443665,0.0000758754,0.0001657441,0.00001195704,0.0008070417,0.0000152015,0.0004165808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1117801,"threshold_uncertainty_score":0.359671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01340046647893619,"score_gpt":0.2224171438011872,"score_spread":0.209016677322251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}