{"id":"W2117858538","doi":"10.15252/embr.201540081","title":"Wnt directs the endosomal flux of LDL‐derived cholesterol and lipid droplet homeostasis","year":2015,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Center of Competence in Research Chemical Biology; Swiss Institute of Bioinformatics; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Endosome; Wnt signaling pathway; Cell biology; Endocytosis; Flux (metallurgy); LRP5; Lipid droplet; WNT3A; Biology; Lipid metabolism; Frizzled; Homeostasis; LRP6; Chemistry; Signal transduction; Biochemistry; Cell; Intracellular","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002599286,0.0004024089,0.0002974561,0.0003471616,0.0003227032,0.001240896,0.0002212729,0.0005374603,0.002191393],"category_scores_gemma":[0.0003563158,0.0002878261,0.0003394864,0.0002360201,0.0003870098,0.0007065423,0.0005489238,0.0008473098,0.0007728728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001469281,"about_ca_system_score_gemma":0.0007824792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002971084,"about_ca_topic_score_gemma":0.004964476,"domain_scores_codex":[0.9997178,0.00004201407,0.00002753608,0.00003447536,0.0001035563,0.00007464347],"domain_scores_gemma":[0.9998035,0.00002106072,0.00005307961,0.00002282233,0.00003761199,0.00006190439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007743101,0.000018369,0.0009063159,0.00008817109,0.00002120162,0.0002761433,0.00004098569,0.0001104091,0.9905038,0.002451974,0.0003675774,0.004440554],"study_design_scores_gemma":[0.00008477431,0.000100405,0.01101313,0.00002082782,0.00006136772,0.0005396274,0.0001540151,0.001399218,0.973435,0.0006144138,0.01256396,0.00001322532],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9653977,0.01142537,0.007785922,0.001748047,0.0002905221,0.00004790568,0.001191521,0.0002072748,0.01190579],"genre_scores_gemma":[0.9803995,0.004496282,0.002244946,0.0001646902,0.00003586078,0.00002056424,0.0006128665,0.00007364823,0.01195167],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002971084,"threshold_uncertainty_score":0.01066047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01340046647893619,"score_gpt":0.2224171438011872,"score_spread":0.209016677322251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}