{"id":"W2117890976","doi":"10.3747/co.19.1018","title":"A Personalized Approach to Treatment: Use of egfr Tyrosine Kinase Inhibitors for the Treatment of Non-Small-Cell Lung Cancer in Canada","year":2012,"lang":"en","type":"article","venue":"Current Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cancer Care Nova Scotia; University of British Columbia; University of Calgary; McGill University; Dalhousie University; Royal Victoria Hospital; Ottawa Hospital; BC Cancer Agency; Montreal General Hospital; Royal Victoria Regional Health Centre","funders":"","keywords":"Medicine; Lung cancer; Epidermal growth factor receptor; Tyrosine kinase; Targeted therapy; Cancer; Oncology; Erlotinib; Personalized medicine; Companion diagnostic; Disease; Internal medicine; Gefitinib; Cancer research; Bioinformatics; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006304609,0.0001807389,0.0002303773,0.0006779423,0.002051135,0.001386339,0.0009821708,0.0007979224,0.004606418],"category_scores_gemma":[0.002277446,0.0001309171,0.0004168449,0.001737403,0.0006747124,0.0004540847,0.0009193723,0.001290979,0.0002838225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0443333,"about_ca_system_score_gemma":0.1171139,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9777938,"about_ca_topic_score_gemma":0.9941677,"domain_scores_codex":[0.9988795,0.0001808502,0.00005956668,0.00008370716,0.0004752606,0.0003212212],"domain_scores_gemma":[0.9986591,0.00009329837,0.0001151676,0.00002541186,0.0004614107,0.0006455455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004511889,0.0004582451,0.182346,0.0008058591,0.0001995122,0.003249666,0.001365401,0.006366119,0.003130839,0.01562173,0.2168138,0.5691916],"study_design_scores_gemma":[0.0004208395,0.0002985508,0.5570199,0.0009674564,0.0003552768,0.003646598,0.003455506,0.006788864,0.002035362,0.006324998,0.4184552,0.0002314947],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.2458073,0.0527762,0.006081334,0.557978,0.001547624,0.0005832126,0.004299114,0.000304572,0.1306227],"genre_scores_gemma":[0.9007673,0.03129648,0.009068157,0.03859307,0.0005900781,0.0001016676,0.001249069,0.0000766247,0.01825761],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.0443333,"threshold_uncertainty_score":0.3216621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0849552293686681,"score_gpt":0.3993099554364875,"score_spread":0.3143547260678194,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}