{"id":"W2117897628","doi":"10.1080/15287394.2011.618979","title":"Transcriptional Modulation in a Leukocyte-Depleted Splenic Cell Population During Prion Disease","year":2011,"lang":"en","type":"article","venue":"Journal of Toxicology and Environmental Health","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"","keywords":"Scrapie; Pathogenesis; Biology; Chronic wasting disease; Follicular dendritic cells; Germinal center; Virology; Population; Spleen; Gene; Transmissible spongiform encephalopathy; Immunology; Disease; Immune system; Antibody; B cell; Pathology; Genetics; T cell; Medicine; Prion protein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001715987,0.0001270783,0.0002051004,0.0003786531,0.000181005,0.0002718616,0.00008587216,0.0001410386,0.0006729692],"category_scores_gemma":[0.0001729153,0.00008890034,0.0001282735,0.0002345921,0.0002413991,0.00007430348,0.0001514987,0.0002742023,0.0002504603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001243029,"about_ca_system_score_gemma":0.0001198669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003657284,"about_ca_topic_score_gemma":0.0007316832,"domain_scores_codex":[0.9998505,0.00001571827,0.00001213458,0.00004846853,0.00003616917,0.00003706534],"domain_scores_gemma":[0.9998518,0.00003273562,0.0000280088,0.00001805159,0.00002728978,0.00004203112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001412916,0.00001165037,0.002333575,0.000007999485,0.000002429631,0.00002162252,0.00003198355,0.000009529787,0.9968601,0.00001432622,0.000008917998,0.0005566296],"study_design_scores_gemma":[0.00003396205,0.0009939303,0.2795537,0.00001146085,0.00005240637,0.0007015888,0.0003619847,0.00112567,0.7154822,0.0001024099,0.001568423,0.00001230013],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975622,0.0003320102,0.001238638,0.00001369689,0.000006298637,0.00001196978,0.0003707078,0.00001865445,0.000445884],"genre_scores_gemma":[0.9952229,0.0002938515,0.001758605,0.00006489367,0.00001312242,0.00005403362,0.001387838,0.00001557742,0.001189151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006729692,"threshold_uncertainty_score":0.002251267,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01288275815640059,"score_gpt":0.2286017763893594,"score_spread":0.2157190182329588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}