{"id":"W2117902695","doi":"10.1002/jgm.624","title":"Heterogeneity of the immune response to adenovirus‐mediated factor VIII gene therapy in different inbred hemophilic mouse strains","year":2004,"lang":"en","type":"article","venue":"The Journal of Gene Medicine","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Queen's University","funders":"Canadian Blood Services; Canada Research Chairs; Heart and Stroke Foundation of Canada","keywords":"Immune system; Genetic enhancement; Biology; Factor IX; Gene; Inbred strain; Virology; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007027488,0.0005967393,0.0002903385,0.001749844,0.0002244857,0.0005899742,0.0003509581,0.0005267087,0.002108445],"category_scores_gemma":[0.000401495,0.0002985251,0.0004466529,0.0003075771,0.0004297444,0.0004040106,0.0004483592,0.001167423,0.0006337741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002812782,"about_ca_system_score_gemma":0.0001651713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002473883,"about_ca_topic_score_gemma":0.0003724553,"domain_scores_codex":[0.9992061,0.0001087638,0.0001264798,0.0002323624,0.0001729603,0.0001533128],"domain_scores_gemma":[0.9990935,0.0001586142,0.0002806619,0.000139441,0.0000900658,0.0002378373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003578291,0.0001832871,0.001783037,0.00002005375,0.00001568171,0.00007573122,0.00005412689,0.0000297817,0.9959221,0.000172567,0.00003429674,0.001351493],"study_design_scores_gemma":[0.000182341,0.003926341,0.08973084,0.0000612802,0.0002187178,0.003507719,0.0002812096,0.0009828593,0.8973064,0.000329071,0.003426546,0.00004662947],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994742,0.0005961682,0.002772679,0.00005057257,0.00001510318,0.00008857362,0.0005916128,0.00008054412,0.00106269],"genre_scores_gemma":[0.9907767,0.0007228222,0.00371445,0.0001329085,0.00002213405,0.000316716,0.001747042,0.0001280862,0.002439234],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002108445,"threshold_uncertainty_score":0.007053494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05228400790326036,"score_gpt":0.3284386786168203,"score_spread":0.2761546707135599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}