{"id":"W2117906220","doi":"10.1158/0008-5472.can-05-2857","title":"Characterization of Common UGT1A8, UGT1A9, and UGT2B7 Variants with Different Capacities to Inactivate Mutagenic 4-Hydroxylated Metabolites of Estradiol and Estrone","year":2006,"lang":"en","type":"article","venue":"Cancer Research","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôpital du Saint-Sacrement; Hôtel-Dieu de Québec","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"UGT2B7; Carcinogen; Estrone; Aromatase; Carcinogenesis; Isozyme; Enzyme; Chemistry; Allele; Glucuronosyltransferase; Biology; Biochemistry; Estrogen; Endocrinology; Genetics; Gene; Microsome; Glucuronidation; Cancer; Breast cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001483792,0.0002911063,0.0002200452,0.0003044829,0.0001026051,0.0001708224,0.0001220354,0.0002421156,0.0007431896],"category_scores_gemma":[0.0003008985,0.0001058143,0.0002820628,0.0002285219,0.0001630904,0.00004999885,0.0001054353,0.0002495773,0.0001863783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000118095,"about_ca_system_score_gemma":0.00009331075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001183089,"about_ca_topic_score_gemma":0.001088181,"domain_scores_codex":[0.9998409,0.00004235413,0.00001369043,0.00003971391,0.00003736926,0.00002589745],"domain_scores_gemma":[0.9998041,0.00003907514,0.00006964416,0.00002023433,0.00002235846,0.00004459135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006361246,0.00009785845,0.05009527,0.00003278945,0.0001253505,0.0005032819,0.0001134724,0.0001731252,0.9437786,0.0001350639,0.00008579582,0.00422331],"study_design_scores_gemma":[0.0001152598,0.00164702,0.5836929,0.00001700361,0.0003491036,0.008646992,0.0002313758,0.003169563,0.3978148,0.0001834659,0.004106749,0.00002587265],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994152,0.00008980553,0.0002692123,0.00001454653,0.000002666377,0.000003537362,0.0001256952,0.000004970605,0.00007442081],"genre_scores_gemma":[0.9986854,0.00006988016,0.0003511388,0.00002247019,0.000005083106,0.00000699598,0.0005700398,0.0000128327,0.0002760302],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001183089,"threshold_uncertainty_score":0.002486169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01773078836526327,"score_gpt":0.2892530785525477,"score_spread":0.2715222901872844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}