{"id":"W2117906220","doi":"10.1158/0008-5472.can-05-2857","title":"Characterization of Common UGT1A8, UGT1A9, and UGT2B7 Variants with Different Capacities to Inactivate Mutagenic 4-Hydroxylated Metabolites of Estradiol and Estrone","year":2006,"lang":"en","type":"article","venue":"Cancer Research","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôpital du Saint-Sacrement; Hôtel-Dieu de Québec","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"UGT2B7; Carcinogen; Estrone; Aromatase; Carcinogenesis; Isozyme; Enzyme; Chemistry; Allele; Glucuronosyltransferase; Biology; Biochemistry; Estrogen; Endocrinology; Genetics; Gene; Microsome; Glucuronidation; Cancer; Breast cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001912601,0.0001185388,0.0002276282,0.0001091091,0.00004983604,0.00001594893,0.0001000436,0.00007815929,0.00001191658],"category_scores_gemma":[0.0000179969,0.0000977653,0.00001856317,0.0001473764,0.0002384207,0.000008417092,0.00009707005,0.00009501849,2.024009e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002109738,"about_ca_system_score_gemma":0.00006096637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000682451,"about_ca_topic_score_gemma":0.0001412759,"domain_scores_codex":[0.9989896,0.0001163115,0.000178755,0.000264547,0.0002149901,0.0002358236],"domain_scores_gemma":[0.999463,0.00001827467,0.00007046509,0.0002266457,0.0001465296,0.0000750682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002387644,0.00005561526,0.005331547,0.00008807106,0.00005802351,0.000001663223,0.0001346094,0.00001285726,0.9931068,0.0002739495,0.000006419938,0.0006916192],"study_design_scores_gemma":[0.000442639,0.0004724172,0.05544061,0.0000593165,0.00001664679,0.000006087049,0.00008727654,0.00003714269,0.9431393,0.0001174108,0.00008667936,0.00009452719],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987235,0.0004998952,0.0001771593,0.00005263505,0.00002125337,0.0003390357,0.000106461,0.000006002339,0.00007405598],"genre_scores_gemma":[0.999118,0.0002954148,0.0001205042,0.000008188334,0.00005042157,0.00006150293,0.00007768119,0.00002074451,0.0002475221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05010906,"threshold_uncertainty_score":0.3986753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01773078836526327,"score_gpt":0.2892530785525477,"score_spread":0.2715222901872844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}