{"id":"W2117910394","doi":"10.1038/ng.3013","title":"Ordering of mutations in preinvasive disease stages of esophageal carcinogenesis","year":2014,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Esophageal Cancer Research and Treatment","field":"Medicine","cited_by":356,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"Medical Research Council; National Institute for Health and Care Research; Cancer Research UK; Wellcome Trust","keywords":"Barrett's esophagus; Biology; Dysplasia; Carcinogenesis; Esophagus; Adenocarcinoma; Genetics; Gene; Mutation; Cancer; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007908048,0.0000856914,0.0001997442,0.0001351214,0.00001528171,0.000002439328,0.00006785783,0.00008076691,0.0000286649],"category_scores_gemma":[0.0001888718,0.00007370845,0.00005866872,0.0002139173,0.00006384197,0.00001410489,0.00003170407,0.000165334,0.00000138837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004404743,"about_ca_system_score_gemma":0.0001900324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003454904,"about_ca_topic_score_gemma":0.00006282028,"domain_scores_codex":[0.9991775,0.00003729573,0.0001800907,0.0001494545,0.0003008224,0.0001548941],"domain_scores_gemma":[0.999334,0.00007428013,0.00005661889,0.0002371537,0.0001579415,0.0001400196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001687924,0.000174914,0.9917123,0.0004280834,0.00005104122,0.00006888888,0.0001926251,0.0006392812,0.001411411,0.0001717856,0.00002456368,0.004956319],"study_design_scores_gemma":[0.001182846,0.0003126535,0.8999935,0.00007110179,0.00007608599,0.000001970053,0.00002947324,0.0002143316,0.09771969,0.0003138378,0.00004022228,0.00004424832],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9761565,0.02300302,0.00006345161,0.0001462142,0.0000382646,0.0003045503,0.00005121807,0.000007351275,0.0002294744],"genre_scores_gemma":[0.9979866,0.0003075901,0.001476216,0.00004396063,0.00005147784,0.00001879123,0.00003383453,0.00001324157,0.00006824697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09630828,"threshold_uncertainty_score":0.3005743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01360522482933418,"score_gpt":0.3098546911026194,"score_spread":0.2962494662732852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}