{"id":"W2117925806","doi":"10.1128/aac.01052-10","title":"Anti-Inflammatory Benefits of Antibiotic-Induced Neutrophil Apoptosis: Tulathromycin Induces Caspase-3-Dependent Neutrophil Programmed Cell Death and Inhibits NF-κB Signaling and CXCL8 Transcription","year":2010,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Microbial infections and disease research","field":"Immunology and Microbiology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Health Research","keywords":"Apoptosis; Neutrophile; Caspase; Programmed cell death; Interleukin 8; Signal transduction; Inflammation; NFKB1; Chemistry; Transcription factor; Cell biology; NF-κB; Transcription (linguistics); Neutrophil extracellular traps; Immunology; Cancer research; Microbiology; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002661698,0.0003935413,0.0005402649,0.0002440464,0.000426807,0.0001176226,0.0001426187,0.0004632951,0.0001167373],"category_scores_gemma":[0.000008571118,0.0003580503,0.00011403,0.0001662562,0.000337276,0.0002158995,0.00008600081,0.0005149904,0.000008833254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001553447,"about_ca_system_score_gemma":0.00007185548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004830334,"about_ca_topic_score_gemma":0.00005145878,"domain_scores_codex":[0.998142,0.0001132293,0.0004854877,0.0006315531,0.00007821819,0.000549535],"domain_scores_gemma":[0.9992278,0.00003875719,0.0002001753,0.0002615155,0.0001420405,0.0001297316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001879135,0.0005221639,0.009374787,0.0002168714,0.0001600301,0.000004072852,0.0004687558,0.000003808725,0.9822747,0.0001238336,0.0002182636,0.006444832],"study_design_scores_gemma":[0.003359566,0.0002983316,0.02860826,0.0001185746,0.0001012221,0.00009586851,0.0001093371,0.000006502183,0.9663931,0.00001810221,0.0005206704,0.0003704895],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997681,0.0005983143,0.000008075562,0.0005063714,0.0003257899,0.0006795052,0.00009118045,0.00006097353,0.00004876612],"genre_scores_gemma":[0.9962788,0.002963668,0.0001041793,0.0003684914,0.00008746166,0.000008091553,0.00006691708,0.00005073189,0.00007168559],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01923347,"threshold_uncertainty_score":0.9998872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01789843552011634,"score_gpt":0.2465000566522194,"score_spread":0.2286016211321031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}