{"id":"W2117925806","doi":"10.1128/aac.01052-10","title":"Anti-Inflammatory Benefits of Antibiotic-Induced Neutrophil Apoptosis: Tulathromycin Induces Caspase-3-Dependent Neutrophil Programmed Cell Death and Inhibits NF-κB Signaling and CXCL8 Transcription","year":2010,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Microbial infections and disease research","field":"Immunology and Microbiology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Health Research","keywords":"Apoptosis; Neutrophile; Caspase; Programmed cell death; Interleukin 8; Signal transduction; Inflammation; NFKB1; Chemistry; Transcription factor; Cell biology; NF-κB; Transcription (linguistics); Neutrophil extracellular traps; Immunology; Cancer research; Microbiology; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001724686,0.0002454252,0.0003361746,0.0001477131,0.0001012668,0.0002869895,0.0001547945,0.0003540949,0.0007281537],"category_scores_gemma":[0.000136275,0.0000846538,0.0001876909,0.0001005463,0.0001812326,0.0002148773,0.0001794179,0.0004545574,0.0002042993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002299077,"about_ca_system_score_gemma":0.0001629745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003628434,"about_ca_topic_score_gemma":0.0009716001,"domain_scores_codex":[0.9998181,0.00004811556,0.00002192951,0.00002937254,0.00004177659,0.00004057363],"domain_scores_gemma":[0.9998885,0.00002128404,0.00003898631,0.00001286293,0.00001751594,0.00002080482],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000105303,0.00001792849,0.0001216821,0.00003851601,0.000002861943,0.00002077549,0.000006214343,0.00000949107,0.9986464,0.000008459828,0.00001156997,0.001010718],"study_design_scores_gemma":[0.00003901753,0.001247193,0.0123211,0.0000176334,0.00002343888,0.0003929709,0.00004024791,0.0005499561,0.9835978,0.00002186576,0.00174367,0.000005063452],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904031,0.006350647,0.002145527,0.0001080903,0.00002377928,0.00002990046,0.0001531291,0.00005556101,0.0007303947],"genre_scores_gemma":[0.9953473,0.0015208,0.001674794,0.00005552625,0.00001261562,0.00002507303,0.0002745127,0.00000600947,0.001083435],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007281537,"threshold_uncertainty_score":0.002435923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01789843552011634,"score_gpt":0.2465000566522194,"score_spread":0.2286016211321031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}