{"id":"W2117937319","doi":"10.1021/bi901524q","title":"Evidence of Kinetic Control of Ligand Binding and Staged Product Release in MurA (Enolpyruvyl UDP-GlcNAc Synthase)-Catalyzed Reactions,","year":2009,"lang":"en","type":"article","venue":"Biochemistry","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Mura; Chemistry; ATP synthase; Catalysis; Ligand (biochemistry); Active site; Stereochemistry; Crystallography; Cocrystal; Enzyme; Hydrogen bond; Biochemistry; Receptor; Molecule; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001858316,0.0002225574,0.0002256385,0.0000608807,0.00008792322,0.0004369035,0.000428905,0.0002370786,0.0008807065],"category_scores_gemma":[0.0007363913,0.0002268726,0.0001257023,0.00008123669,0.0002915498,0.0004403023,0.0001789174,0.0004529901,0.0003086533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004421386,"about_ca_system_score_gemma":0.0001633718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005387738,"about_ca_topic_score_gemma":0.0005032794,"domain_scores_codex":[0.9998196,0.00002537427,0.00001132818,0.00006654538,0.00005588952,0.00002131859],"domain_scores_gemma":[0.9996768,0.0001098343,0.00008531952,0.0000406205,0.00004396918,0.00004348902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004340575,0.00006482623,0.001061052,0.0001064593,0.00001889109,0.0000965453,0.00005097784,0.0008315113,0.9905478,0.0008012383,0.0001478876,0.005838644],"study_design_scores_gemma":[0.00002316807,0.0001662382,0.002972422,0.000003426771,0.000006754412,0.0002031883,0.00001670302,0.007883987,0.9874271,0.000151574,0.001133108,0.00001237426],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872252,0.00130977,0.009410156,0.00006911266,0.00002180408,0.00002135708,0.0002814757,0.000172192,0.001488972],"genre_scores_gemma":[0.9966835,0.000261755,0.002273518,0.00001036582,0.00000250155,0.00001064431,0.0002098738,0.00001666311,0.000531117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008807065,"threshold_uncertainty_score":0.003207922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01665620494040589,"score_gpt":0.2399228962307252,"score_spread":0.2232666912903193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}