{"id":"W2117944708","doi":"10.1128/aac.00214-11","title":"Antiviral Activity and Mode of Action of TMC647078, a Novel Nucleoside Inhibitor of the Hepatitis C Virus NS5B Polymerase","year":2011,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Hepatitis C virus research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Cancer Research Society","keywords":"NS5B; Hepatitis C virus; Virology; Biology; Mode of action; Nucleoside; Virus; Pharmacology; Hepacivirus; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001035199,0.0003264871,0.0002401034,0.0001521866,0.00009500454,0.0001490261,0.0001633192,0.0002072006,0.0005456629],"category_scores_gemma":[0.00006384941,0.00006907597,0.0001894959,0.00009646388,0.0001164571,0.00009731545,0.0000803389,0.0002524172,0.0002904132],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001623025,"about_ca_system_score_gemma":0.0001849557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005833724,"about_ca_topic_score_gemma":0.0005726224,"domain_scores_codex":[0.9999354,0.00001373876,0.000006457615,0.000009666241,0.00001982098,0.00001495899],"domain_scores_gemma":[0.9999707,0.000005663608,0.000007757486,0.000002668289,0.000005437898,0.000007708819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001254622,0.0000335246,0.0001703695,0.00008174474,0.000004527275,0.00007572997,0.000007792743,0.0002661732,0.9931061,0.0000489911,0.00004202172,0.006037611],"study_design_scores_gemma":[0.00002876791,0.001343247,0.00245949,0.00000700449,0.00001956107,0.0006696492,0.000007181122,0.0008171394,0.9920802,0.00001814477,0.002543526,0.000006223331],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9697378,0.02333837,0.002584057,0.0001051579,0.00005303497,0.00005343141,0.0004699644,0.0000635876,0.003594679],"genre_scores_gemma":[0.9873208,0.008141129,0.002016932,0.00003985504,0.00002780184,0.00002022822,0.0006213455,0.00000811819,0.001803891],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005833724,"threshold_uncertainty_score":0.001825392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0420307890200221,"score_gpt":0.3053401539861568,"score_spread":0.2633093649661347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}