{"id":"W2117965089","doi":"10.2174/0929867003375371","title":"Androgen Receptor Antagonists (Antiandrogens) Structure-Activity Relationships","year":2000,"lang":"en","type":"review","venue":"Current Medicinal Chemistry","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":234,"is_retracted":false,"has_abstract":true,"ca_institutions":"Wilfrid Laurier University; Centre hospitalier de l'Université Laval; Centre hospitalier universitaire de Québec","funders":"","keywords":"Antiandrogens; Flutamide; Prostate cancer; Antiandrogen; Androgen receptor; Internal medicine; Endocrinology; Androgen; Testosterone (patch); Dihydrotestosterone; Medicine; Enzalutamide; Chemistry; Hormone; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005529512,0.0005997976,0.0005215744,0.000568334,0.0002107894,0.0006865357,0.0004392034,0.0005332172,0.01363994],"category_scores_gemma":[0.0004607971,0.0002474008,0.0005942683,0.0004703175,0.0001475128,0.0002858565,0.0001915546,0.0006434654,0.004026674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003306514,"about_ca_system_score_gemma":0.0002799869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000296149,"about_ca_topic_score_gemma":0.001215209,"domain_scores_codex":[0.999625,0.0001023564,0.00003135357,0.00004779175,0.0001429534,0.00005048836],"domain_scores_gemma":[0.999741,0.00007255374,0.00007856244,0.00001469536,0.00005837468,0.00003477378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00238328,0.002314621,0.00517579,0.003597821,0.0004751764,0.0008880335,0.0001092968,0.002144076,0.4488078,0.00582192,0.01609387,0.5121883],"study_design_scores_gemma":[0.002039364,0.04054198,0.05475941,0.0004964992,0.0007887525,0.01025196,0.0001616614,0.002136936,0.1839095,0.003476454,0.7013509,0.00008658344],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.235524,0.5762045,0.008830126,0.003501615,0.001359524,0.00144546,0.004610827,0.0007575638,0.1677663],"genre_scores_gemma":[0.7006053,0.2240003,0.006599005,0.003818581,0.001486817,0.0005832558,0.003434959,0.00004937201,0.05942253],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01363994,"threshold_uncertainty_score":0.0456301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1085032400324328,"score_gpt":0.3998477820769277,"score_spread":0.2913445420444949,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}