{"id":"W2117966967","doi":"10.1002/ibd.21038","title":"Fontolizumab in moderate to severe Crohnʼs disease: A phase 2, randomized, double-blind, placebo-controlled, multiple-dose study","year":2009,"lang":"en","type":"article","venue":"Inflammatory Bowel Diseases","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":220,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; University of Manitoba; Western University","funders":"","keywords":"Medicine; Placebo; Exacerbation; Internal medicine; Adverse effect; Crohn's disease; Gastroenterology; Clinical endpoint; Randomized controlled trial; C-reactive protein; Inflammatory bowel disease; Clinical trial; Subcutaneous injection; Immunology; Disease; Inflammation; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001832244,0.00135103,0.003147884,0.0003833124,0.0004414408,0.000834351,0.0008844436,0.001561041,0.003666348],"category_scores_gemma":[0.001016788,0.0006519187,0.001072617,0.0003364453,0.0008884409,0.0007775701,0.0002317865,0.001911476,0.0006371277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004384845,"about_ca_system_score_gemma":0.0009052305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003636676,"about_ca_topic_score_gemma":0.0008800376,"domain_scores_codex":[0.9995556,0.000205126,0.00003070243,0.00008286519,0.00005691402,0.00006867741],"domain_scores_gemma":[0.9994418,0.0001227983,0.0001196353,0.00004527158,0.00004682627,0.0002237295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9047064,0.03326558,0.001403019,0.001315926,0.001147523,0.0001891935,0.0001139909,0.0004743116,0.02071819,0.0001279349,0.001486581,0.03505127],"study_design_scores_gemma":[0.8992473,0.09611272,0.002804239,0.00002563103,0.000212324,0.00009253552,0.00001145679,0.0003140524,0.0004984995,0.00005258811,0.000615713,0.00001289318],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882663,0.005068062,0.0009019602,0.0005057238,0.000385198,0.003174667,0.0004991419,0.0001608006,0.001038043],"genre_scores_gemma":[0.9840462,0.004617853,0.002326196,0.001488947,0.0005858843,0.003923071,0.0009164124,0.00002860974,0.002066838],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003666348,"threshold_uncertainty_score":0.01226515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01335467848619606,"score_gpt":0.285055303593755,"score_spread":0.271700625107559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}