{"id":"W2117966967","doi":"10.1002/ibd.21038","title":"Fontolizumab in moderate to severe Crohnʼs disease: A phase 2, randomized, double-blind, placebo-controlled, multiple-dose study","year":2009,"lang":"en","type":"article","venue":"Inflammatory Bowel Diseases","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":220,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; University of Manitoba; Western University","funders":"","keywords":"Medicine; Placebo; Exacerbation; Internal medicine; Adverse effect; Crohn's disease; Gastroenterology; Clinical endpoint; Randomized controlled trial; C-reactive protein; Inflammatory bowel disease; Clinical trial; Subcutaneous injection; Immunology; Disease; Inflammation; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000805522,0.001005313,0.001245621,0.0004875525,0.0003106706,0.0002891059,0.0008314928,0.0002439673,0.0001162291],"category_scores_gemma":[0.001134908,0.0009547155,0.0008325381,0.0002573912,0.0001648054,0.00008176021,0.0002646191,0.0002821586,0.0001555793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001525381,"about_ca_system_score_gemma":0.0008249682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002570264,"about_ca_topic_score_gemma":0.0003622929,"domain_scores_codex":[0.994184,0.0009116335,0.001483227,0.001500873,0.000787798,0.001132479],"domain_scores_gemma":[0.9959959,0.0001449789,0.0003741104,0.001591475,0.0003145174,0.001579038],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9477006,0.003742717,0.03249514,0.0000825836,0.0003764122,0.003717221,0.0003327679,0.009118527,0.0005467149,0.0001604374,0.001122637,0.0006042715],"study_design_scores_gemma":[0.8927735,0.0003770321,0.09993698,0.0001074148,0.0005228757,0.00001198765,0.0002663895,0.003868233,0.0000910615,0.0002858837,0.0004499612,0.001308676],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851816,0.001104049,0.0002094877,0.000223649,0.0002896028,0.01188959,0.00031431,0.0001928574,0.0005949077],"genre_scores_gemma":[0.9934065,0.00004832161,0.00006208886,0.0009239321,0.0005436203,0.003835028,0.0003303675,0.0001157317,0.0007343534],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06744184,"threshold_uncertainty_score":0.9992903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01335467848619606,"score_gpt":0.285055303593755,"score_spread":0.271700625107559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}