{"id":"W2117981720","doi":"10.1530/rep-09-0545","title":"Calpain modulates capacitation and acrosome reaction through cleavage of the spectrin cytoskeleton","year":2010,"lang":"en","type":"article","venue":"Reproduction","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional; Consejo Nacional de Ciencia y Tecnología","keywords":"Capacitation; Calpain; Acrosome reaction; Sperm; Cell biology; Spectrin; Acrosome; Oocyte activation; Cytoskeleton; Spermatozoon; Chemistry; Oocyte; Calpastatin; Human fertilization; Cytoplasm; Biology; Biochemistry; Anatomy; Embryo; Genetics; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001072924,0.0002562971,0.0001665838,0.0001996952,0.000120869,0.0002175168,0.0001937642,0.0002649091,0.0008868982],"category_scores_gemma":[0.0001273997,0.0001003735,0.0001400465,0.0001152932,0.0002378991,0.0002739342,0.0001831637,0.0002907704,0.0001519094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002195724,"about_ca_system_score_gemma":0.0001202091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003674105,"about_ca_topic_score_gemma":0.0004911946,"domain_scores_codex":[0.9999317,0.00001164839,0.000003819543,0.00001420275,0.00001373073,0.00002498489],"domain_scores_gemma":[0.9999406,0.000009256297,0.00002272269,0.000003880153,0.000009554915,0.0000139818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008163379,0.00001725637,0.0003047909,0.00002958176,0.000003541113,0.0001435301,0.00002150086,0.00002197395,0.9979249,0.0001150884,0.00003539633,0.001300858],"study_design_scores_gemma":[0.00005009995,0.0006809173,0.07717403,0.00001233375,0.00002778928,0.0008445676,0.0000863034,0.001254951,0.9164908,0.0003198095,0.003048952,0.000009444993],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876715,0.007572313,0.002400273,0.0002339409,0.00004329177,0.00003219298,0.00007902116,0.00005084561,0.001916725],"genre_scores_gemma":[0.9956369,0.002191774,0.0006536632,0.00004614659,0.00001922684,0.00001270856,0.00006322583,0.00000552907,0.001370856],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008868982,"threshold_uncertainty_score":0.00296694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005726719845724637,"score_gpt":0.2236848324765262,"score_spread":0.2179581126308015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}