{"id":"W2117981720","doi":"10.1530/rep-09-0545","title":"Calpain modulates capacitation and acrosome reaction through cleavage of the spectrin cytoskeleton","year":2010,"lang":"en","type":"article","venue":"Reproduction","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional; Consejo Nacional de Ciencia y Tecnología","keywords":"Capacitation; Calpain; Acrosome reaction; Sperm; Cell biology; Spectrin; Acrosome; Oocyte activation; Cytoskeleton; Spermatozoon; Chemistry; Oocyte; Calpastatin; Human fertilization; Cytoplasm; Biology; Biochemistry; Anatomy; Embryo; Genetics; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000309852,0.0000781851,0.00006741516,0.00002302277,0.000110433,0.00001051804,0.00004013224,0.0001217863,0.000004399513],"category_scores_gemma":[0.0002438645,0.00006062003,0.00004976514,0.000112189,0.0001100491,0.00001362495,0.00002626884,0.000116955,0.00000183074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001026608,"about_ca_system_score_gemma":0.00001834988,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007253676,"about_ca_topic_score_gemma":0.00004889201,"domain_scores_codex":[0.9992877,0.00005848464,0.0001530512,0.000312456,0.000105053,0.00008320567],"domain_scores_gemma":[0.9993852,0.00000534309,0.0001226677,0.000393694,0.0000740255,0.00001902338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004932581,0.00002525635,0.001179187,0.00001636531,0.00001018259,4.771809e-8,0.00008481579,0.0000323656,0.992164,0.0004677323,0.0004632275,0.005507533],"study_design_scores_gemma":[0.000184795,0.00006059129,0.04675366,0.000005897488,0.00001117388,0.00003393017,0.00006648997,0.00007363192,0.9375566,0.0008744455,0.01430678,0.00007194802],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968942,0.00008547248,0.0009006897,0.0007221214,0.0007758425,0.0002438958,0.000002631322,0.00001631861,0.0003587929],"genre_scores_gemma":[0.9980922,0.00005800202,0.0003658586,0.00002958367,0.0005748737,0.000009893235,0.00003050453,0.00001062553,0.0008283972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05460731,"threshold_uncertainty_score":0.2472013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005726719845724637,"score_gpt":0.2236848324765262,"score_spread":0.2179581126308015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}