{"id":"W2117988243","doi":"10.2165/11593390-000000000-00000","title":"Impact of Intravenous Naltrexone on Intravenous Morphine-Induced High, Drug Liking, and Euphoric Effects in Experienced, Nondependent Male Opioid Users","year":2011,"lang":"en","type":"article","venue":"Drugs in R&D","topic":"Opioid Use Disorder Treatment","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Celerion (Canada)","funders":"Shionogi; Astellas Pharma; Purdue University; Eisai; Bayer HealthCare; Boston Scientific Corporation; Purdue Pharma; Gilead Sciences; GlaxoSmithKline; Nevro; Teva Pharmaceutical Industries; AstraZeneca; Pfizer","keywords":"Euphoriant; Naltrexone; Morphine; Medicine; Heroin; Opioid; Anesthesia; Narcotic antagonist; Visual analogue scale; Pharmacology; Drug; Internal medicine; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005530039,0.0002542439,0.0003466487,0.0001130234,0.0001243959,0.0002546641,0.0001961825,0.0002518196,0.001829649],"category_scores_gemma":[0.002064166,0.0001692769,0.0003476377,0.00008427685,0.0002709228,0.0002488984,0.0001789129,0.0004189968,0.0001229082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000184258,"about_ca_system_score_gemma":0.0001774412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003249445,"about_ca_topic_score_gemma":0.0006510464,"domain_scores_codex":[0.9995373,0.0002449206,0.00004326422,0.00004521425,0.00008218708,0.00004701803],"domain_scores_gemma":[0.9990517,0.0003851791,0.0002460529,0.00004798844,0.0000418787,0.0002271424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4521723,0.08992577,0.1181068,0.001234018,0.00125906,0.0005012296,0.0005786,0.001536153,0.1810459,0.000122012,0.0003507559,0.1531674],"study_design_scores_gemma":[0.01372464,0.6624467,0.3084748,0.00003432741,0.0003222842,0.0003884639,0.0001955233,0.00133336,0.01259234,0.00003577211,0.000425487,0.00002634804],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997205,0.00006499606,0.0000219503,0.000005926986,0.000003031709,0.00003471177,0.00002214108,0.000002250785,0.0001245098],"genre_scores_gemma":[0.999518,0.00008409788,0.0001378998,0.00002891852,0.000009224553,0.00003478107,0.00004391539,0.000001142431,0.0001420001],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001829649,"threshold_uncertainty_score":0.006120801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0124207090589173,"score_gpt":0.2684139299841857,"score_spread":0.2559932209252684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}