{"id":"W2117992130","doi":"10.1128/iai.70.7.3673-3680.2002","title":"Strain-Dependent Induction of Enterocyte Apoptosis by<i>Giardia lamblia</i>Disrupts Epithelial Barrier Function in a Caspase-3-Dependent Manner","year":2002,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Parasitic Infections and Diagnostics","field":"Immunology and Microbiology","cited_by":231,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Fondation pour la Recherche Médicale; Crohn's and Colitis Foundation of Canada; Natural Sciences and Engineering Research Council of Canada; Crohn's and Colitis Foundation","keywords":"Enterocyte; Giardia lamblia; Apoptosis; Biology; Barrier function; Tight junction; Cell biology; Caspase 3; Molecular biology; Microbiology; Biochemistry; Small intestine; Programmed cell death","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003402616,0.0002091011,0.0002816051,0.0003653412,0.0003065926,0.0000262267,0.00006121401,0.0003372038,0.001294528],"category_scores_gemma":[0.0001708545,0.0002078561,0.00009141033,0.0002541178,0.0001654892,0.000244847,0.00005844523,0.0005278623,0.0001795221],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000942776,"about_ca_system_score_gemma":0.000017072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003141696,"about_ca_topic_score_gemma":0.0005099621,"domain_scores_codex":[0.9986113,0.0003619522,0.000422798,0.0002520713,0.00006309734,0.0002887778],"domain_scores_gemma":[0.9993073,0.0001411606,0.000158961,0.0002498713,0.0001020286,0.00004064985],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002473119,0.00144184,0.06254458,0.00005678521,0.0002761413,0.000003202201,0.0009937844,0.00009433769,0.9157078,0.0006608515,0.002645046,0.01532832],"study_design_scores_gemma":[0.008959145,0.001742403,0.4686129,0.0001762157,0.0003446304,0.0004336645,0.00111609,0.0001066739,0.4969901,0.0003229074,0.02028546,0.0009098617],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940428,0.0004798537,0.0006886626,0.000053714,0.001718223,0.0002616307,0.0001992742,0.00005948737,0.002496332],"genre_scores_gemma":[0.9976989,0.0009333744,0.000006774149,0.00008645135,0.00004089693,0.00004552881,0.0001013914,0.00001495476,0.001071753],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4187177,"threshold_uncertainty_score":0.9996184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01537366547775102,"score_gpt":0.2378031283646002,"score_spread":0.2224294628868492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}