{"id":"W2117996655","doi":"10.1128/aac.02705-14","title":"Fosmidomycin Decreases Membrane Hopanoids and Potentiates the Effects of Colistin on Burkholderia multivorans Clinical Isolates","year":2014,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Cystic Fibrosis Canada; Howard Hughes Medical Institute; National Aeronautics and Space Administration; California Institute of Technology; University of Toronto","keywords":"Colistin; Polymyxin; Microbiology; Antimicrobial; Biology; Burkholderia cepacia complex; Membrane permeability; Polymyxin B; Bacteria; Burkholderia; Biochemistry; Antibiotics; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001467687,0.0003607688,0.0003777998,0.0001969733,0.00009692473,0.0002043681,0.000150021,0.0002256723,0.001262874],"category_scores_gemma":[0.0003451033,0.00009159151,0.000159438,0.0001056864,0.0001469584,0.0001750901,0.0002003861,0.0003062816,0.0001948546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001350891,"about_ca_system_score_gemma":0.0001377901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007597806,"about_ca_topic_score_gemma":0.001159629,"domain_scores_codex":[0.9998235,0.00005688711,0.00001803862,0.00002661855,0.0000362073,0.00003877337],"domain_scores_gemma":[0.9998317,0.00004032432,0.00003796575,0.000009202744,0.00003028947,0.00005045745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005219214,0.0001318436,0.0005717661,0.00006102532,0.000008615881,0.00006127053,0.00003163196,0.00004821284,0.9948226,0.00001518526,0.00007474568,0.003651091],"study_design_scores_gemma":[0.0000500559,0.003914942,0.02371746,0.00002885977,0.00003732379,0.000478966,0.0001208656,0.0008469301,0.9681582,0.00002840774,0.002609147,0.000008843518],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967475,0.001719152,0.0002777414,0.0001230897,0.00002454558,0.00002547754,0.0001465379,0.00003301091,0.0009027609],"genre_scores_gemma":[0.9976343,0.0005719926,0.0006394394,0.00006176553,0.0000182822,0.00001701209,0.0002089748,0.00000611543,0.0008421686],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001262874,"threshold_uncertainty_score":0.004224718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007229103242162522,"score_gpt":0.2586714463117361,"score_spread":0.2514423430695736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}