{"id":"W2118010724","doi":"10.1158/1078-0432.ccr-10-0527","title":"“Contextual” Synthetic Lethality and/or Loss of Heterozygosity: Tumor Hypoxia and Modification of DNA Repair","year":2010,"lang":"en","type":"review","venue":"Clinical Cancer Research","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":121,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Synthetic lethality; Loss of heterozygosity; DNA repair; Cancer research; Carcinogenesis; Genome instability; Biology; Hypoxia (environmental); Phenotype; DNA damage; DNA mismatch repair; Context (archaeology); Tumor hypoxia; DNA; Genetics; Cancer; Medicine; Chemistry; Internal medicine; Gene; Radiation therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005321167,0.0008844205,0.00126879,0.001883591,0.0002805125,0.0008818381,0.0009643151,0.001301414,0.00210393],"category_scores_gemma":[0.0006305574,0.0002508245,0.0002917364,0.00172242,0.0009763904,0.001663604,0.0006103276,0.001483035,0.002385039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009153478,"about_ca_system_score_gemma":0.000796031,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00108669,"about_ca_topic_score_gemma":0.001975095,"domain_scores_codex":[0.9998733,0.00002551064,0.00001668411,0.00002478828,0.00004669305,0.00001300895],"domain_scores_gemma":[0.9997351,0.0001165809,0.0000382921,0.00001267023,0.00006689651,0.00003052691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007798093,0.00006746808,0.0002170355,0.007001358,0.00005930711,0.0003647276,0.00005214519,0.0003738274,0.002434319,0.006715335,0.03277955,0.949857],"study_design_scores_gemma":[0.00001675773,0.00006289556,0.0007736581,0.001224482,0.00004135225,0.003017228,0.00005877648,0.00009020825,0.0007827569,0.003402348,0.9905106,0.00001890275],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001513266,0.9975568,0.0002634284,0.0003735424,0.0002331777,0.000003774463,0.00001099922,0.00001028818,0.001396612],"genre_scores_gemma":[0.0008803425,0.9974828,0.0002473903,0.0002623514,0.0001692207,0.000006636557,0.00002018293,0.000002121155,0.0009289362],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00210393,"threshold_uncertainty_score":0.007038355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2810343166911639,"score_gpt":0.5143855926620859,"score_spread":0.233351275970922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}