{"id":"W2118021919","doi":"10.1517/17460441.2011.573783","title":"New methods for multiple sclerosis drug discovery","year":2011,"lang":"en","type":"article","venue":"Expert Opinion on Drug Discovery","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"Multiple sclerosis; Pathogenesis; Disease; Drug discovery; Drug; Drug development; Immune system; Apoptosis; Immunology; Medicine; Biology; Bioinformatics; Pharmacology; Genetics; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025957,0.0002733867,0.000220917,0.00006740209,0.0001525115,0.00009097837,0.0002482103,0.0001433314,0.00004775449],"category_scores_gemma":[0.00007325582,0.0002310759,0.0002930374,0.0000765448,0.00004157921,0.00004923126,0.0001290154,0.00007267058,0.00001071791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002764798,"about_ca_system_score_gemma":0.00008962465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002148529,"about_ca_topic_score_gemma":0.00002446763,"domain_scores_codex":[0.9985561,0.00009942517,0.0002843834,0.0006007896,0.0001384473,0.0003208421],"domain_scores_gemma":[0.9991236,0.00005619303,0.0001231467,0.0005303529,0.0000408085,0.0001259249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009973033,0.0003289921,0.0001731678,0.00002663824,0.0001164381,5.186982e-7,0.0009971686,0.00009363659,0.7887688,0.005088436,0.07680984,0.126599],"study_design_scores_gemma":[0.001241029,0.0002161692,0.0009028987,0.00006572077,0.00000580754,0.000002037436,0.0002805777,0.0002955044,0.7664627,0.0008552702,0.2292657,0.0004065745],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.05712715,0.01035379,0.9226684,0.0005842234,0.00576636,0.001231809,0.00009298326,0.00007935533,0.002095906],"genre_scores_gemma":[0.7790335,0.009697521,0.1660475,0.001699414,0.003472427,0.0003621887,0.001295194,0.000204775,0.03818749],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.7566209,"threshold_uncertainty_score":0.9423001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05481432085617162,"score_gpt":0.3173175077206489,"score_spread":0.2625031868644773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}