{"id":"W2118024111","doi":"10.1124/mol.58.2.373","title":"From Agonist To Antagonist: Fab Fragments of an Agonist-Like Monoclonal Anti-β<sub>2</sub>-Adrenoceptor Antibody Behave as Antagonists","year":2000,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":85,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Agonist; Chemistry; Adenylyl cyclase; Monoclonal antibody; Receptor; Partial agonist; Molecular biology; Antibody; Biophysics; Biochemistry; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005186759,0.0006250055,0.0005615497,0.0004489376,0.0003906834,0.0007799378,0.0006841137,0.001066479,0.003681269],"category_scores_gemma":[0.0005613129,0.0005136558,0.0005842107,0.0001921042,0.0004569146,0.000742058,0.0003164158,0.001551945,0.004172697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005112136,"about_ca_system_score_gemma":0.0002980428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004961225,"about_ca_topic_score_gemma":0.000555777,"domain_scores_codex":[0.9996186,0.00006802609,0.00002234694,0.00006002548,0.00009464035,0.0001362153],"domain_scores_gemma":[0.9997538,0.00007330338,0.00002991682,0.00003034629,0.00006265761,0.00004996383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002216429,0.00003190104,0.0002339881,0.00005125802,0.00001420257,0.000199298,0.00005010335,0.0001381491,0.9910216,0.001929058,0.0007789651,0.005329918],"study_design_scores_gemma":[0.0001342551,0.001092252,0.00473452,0.000034399,0.00009147688,0.0035163,0.00009893226,0.00181803,0.9595615,0.001684507,0.02720195,0.00003168797],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8774089,0.02346774,0.05126707,0.004096722,0.0016245,0.0003165781,0.0007586644,0.00131478,0.03974515],"genre_scores_gemma":[0.9515232,0.008264265,0.01163058,0.004390461,0.0003151533,0.0001198085,0.0008065701,0.0002425215,0.02270744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003681269,"threshold_uncertainty_score":0.01231509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00650766770309406,"score_gpt":0.2858949982614332,"score_spread":0.2793873305583391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}