{"id":"W2118034418","doi":"10.7554/elife.04316","title":"Knockdown of hypothalamic RFRP3 prevents chronic stress-induced infertility and embryo resorption","year":2015,"lang":"en","type":"article","venue":"eLife","topic":"Hypothalamic control of reproductive hormones","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institute for Advanced Research","funders":"National Institute of Mental Health; National Institutes of Health; University of Virginia; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Foundation for the National Institutes of Health","keywords":"Infertility; Chronic stress; Gene knockdown; Biology; Pregnancy; Andrology; Embryo; Mating; Endocrinology; Internal medicine; Medicine; Physiology; Cell biology; Genetics; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005559357,0.0001792736,0.0004426824,0.0001165048,0.00002816667,0.000009427623,0.00008968235,0.0001143716,0.00003470937],"category_scores_gemma":[0.0007072372,0.0001582157,0.00007237808,0.0001275095,0.0001011369,0.0001445151,0.00009233351,0.0002003777,0.00003655873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001820453,"about_ca_system_score_gemma":0.0003334534,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001193692,"about_ca_topic_score_gemma":0.00004450349,"domain_scores_codex":[0.9983698,0.0001057586,0.0003829526,0.0004139234,0.0004819706,0.0002455702],"domain_scores_gemma":[0.9986936,0.0000521901,0.0001652944,0.00059712,0.0002902843,0.0002014914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007329769,0.0005558488,0.2853399,0.0003306092,0.0002532609,0.00002490551,0.0007395251,0.00001817549,0.6825699,0.00007573792,0.001191246,0.02816793],"study_design_scores_gemma":[0.003616692,0.0006206801,0.8852394,0.0001330687,0.0001269691,0.00004399169,0.00009490582,0.0003007338,0.1084432,0.0001528142,0.001073918,0.000153609],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936495,0.003622831,0.00005369366,0.0007751599,0.0001704279,0.0006054444,0.00001283734,0.00006562685,0.001044437],"genre_scores_gemma":[0.9983367,0.0000670336,0.000240954,0.00004805218,0.00033513,0.00002173004,0.00001692931,0.00002389625,0.000909518],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5998995,"threshold_uncertainty_score":0.6451848,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04153674009080531,"score_gpt":0.293533424010383,"score_spread":0.2519966839195776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}