{"id":"W2118046722","doi":"10.1161/circresaha.109.212217","title":"The RAGE Axis","year":2010,"lang":"en","type":"review","venue":"Circulation Research","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":378,"is_retracted":false,"has_abstract":true,"ca_institutions":"Columbia College","funders":"National Institute on Aging","keywords":"Rage (emotion); Glycation; Proinflammatory cytokine; Receptor; Advanced glycation end-product; Oxidative stress; Reactive oxygen species; Immunoglobulin superfamily; HMGB1; Cell biology; Chemistry; Internal medicine; Endocrinology; Medicine; Inflammation; Biology; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003680244,0.001084929,0.0009253787,0.000837803,0.0002412845,0.001117989,0.0007601764,0.001146809,0.004565249],"category_scores_gemma":[0.0003625527,0.0002080996,0.0003138031,0.0005849684,0.0004645658,0.001070939,0.0005888855,0.00182293,0.003993243],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000589044,"about_ca_system_score_gemma":0.0007311525,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004821401,"about_ca_topic_score_gemma":0.0007639978,"domain_scores_codex":[0.9998426,0.00003091707,0.00001308727,0.00003030746,0.00006062755,0.00002237466],"domain_scores_gemma":[0.9998943,0.00003043218,0.00001648926,0.00000534527,0.00003468808,0.00001885144],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001436744,0.00006635671,0.0002218422,0.004477643,0.0001218686,0.0005183466,0.00005609617,0.0003692865,0.007194749,0.00863197,0.05529589,0.9229022],"study_design_scores_gemma":[0.00002793701,0.00005153217,0.0004344714,0.0003473075,0.00002811399,0.001168316,0.00002097192,0.00004106955,0.0009707916,0.001491218,0.9954093,0.000008889956],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003427645,0.9921793,0.0005373069,0.0009216021,0.0008086801,0.00001175312,0.00003803061,0.00003498569,0.005125561],"genre_scores_gemma":[0.003465799,0.9883243,0.0005643432,0.0006434985,0.0005790923,0.00002229272,0.00007072562,0.000003661159,0.006326354],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004565249,"threshold_uncertainty_score":0.01527226,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1369466523156476,"score_gpt":0.4805380139205883,"score_spread":0.3435913616049407,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}