{"id":"W2118046722","doi":"10.1161/circresaha.109.212217","title":"The RAGE Axis","year":2010,"lang":"en","type":"review","venue":"Circulation Research","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":378,"is_retracted":false,"has_abstract":true,"ca_institutions":"Columbia College","funders":"National Institute on Aging","keywords":"Rage (emotion); Glycation; Proinflammatory cytokine; Receptor; Advanced glycation end-product; Oxidative stress; Reactive oxygen species; Immunoglobulin superfamily; HMGB1; Cell biology; Chemistry; Internal medicine; Endocrinology; Medicine; Inflammation; Biology; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002838248,0.0002166771,0.0003248776,0.0001887847,0.0007897916,0.0001804642,0.0008914915,0.0005110901,0.00007537508],"category_scores_gemma":[0.002628392,0.0001497576,0.000217426,0.0006633172,0.0004331342,0.000005183797,0.0003781365,0.001402116,0.000458125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006066814,"about_ca_system_score_gemma":0.0008181393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007372825,"about_ca_topic_score_gemma":0.00002173191,"domain_scores_codex":[0.9966988,0.000875477,0.0003903125,0.0006689715,0.0007767203,0.0005897274],"domain_scores_gemma":[0.9971269,0.000352756,0.0001218366,0.001559093,0.0006999172,0.0001395128],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000005195109,0.00001380909,0.00000395502,0.0006178187,0.00003319438,0.000001598587,0.0000057547,0.000009383431,0.0002601037,0.0004625214,0.002958898,0.9956278],"study_design_scores_gemma":[0.0000639647,0.00002656155,0.00001792198,0.000166751,0.00001157888,0.00001958109,0.000008262956,0.00001032103,0.00005428906,0.0002511262,0.9992099,0.000159717],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00001621299,0.9938939,0.0002900308,0.0001716442,0.000249854,0.001109718,0.00001817447,0.00001463347,0.004235792],"genre_scores_gemma":[0.0001268626,0.9877091,0.00007864895,0.000009003628,0.0009919786,0.0003544315,0.0005134227,0.00007123411,0.01014531],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.996251,"threshold_uncertainty_score":0.6106938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1369466523156476,"score_gpt":0.4805380139205883,"score_spread":0.3435913616049407,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}