{"id":"W2118048714","doi":"10.1016/j.chembiol.2015.07.017","title":"Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors","year":2015,"lang":"en","type":"article","venue":"Chemistry & Biology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministero dello Sviluppo Economico; Danmarks Frie Forskningsfond; Ontario Ministry of Economic Development and Innovation; Ontario Genomics Institute; National Institute of General Medical Sciences; Diamond Light Source; Wellcome Trust; Ludwig Institute for Cancer Research; Deutsche Forschungsgemeinschaft; GlaxoSmithKline; Ontario Genomics; Crohn's and Colitis Foundation of America; Genome Canada; Leona M. and Harry B. Helmsley Charitable Trust; Pfizer; Eli Lilly and Company","keywords":"Ponatinib; Pharmacology; Inflammasome; Autophosphorylation; Chemistry; Signal transduction; Protein kinase A; Kinase; Cancer research; Inflammation; Cell biology; Biology; Tyrosine kinase; Dasatinib; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002424692,0.0003318574,0.0004517912,0.0001293296,0.0001363507,0.0003825506,0.0002743348,0.0001845854,0.00124418],"category_scores_gemma":[0.0002276247,0.000147376,0.0002545068,0.0001904851,0.0002189215,0.000209292,0.0001474987,0.0006283281,0.0004546968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000410728,"about_ca_system_score_gemma":0.0003232614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000280359,"about_ca_topic_score_gemma":0.0006234263,"domain_scores_codex":[0.9998124,0.00004366869,0.00002113999,0.00002617355,0.00004523623,0.00005132329],"domain_scores_gemma":[0.9999555,0.000007595801,0.00001433405,0.000006220738,0.000005039677,0.00001134025],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001030335,0.0002068817,0.0004201139,0.0002580759,0.00006436832,0.0002040915,0.00002271948,0.001181695,0.9841225,0.0006845223,0.0009734941,0.01083113],"study_design_scores_gemma":[0.0006807638,0.00169942,0.003534012,0.00001857963,0.00005959651,0.001922743,0.0000312207,0.003999566,0.9711665,0.0002832484,0.01658387,0.0000205158],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9698246,0.01308163,0.00563676,0.0004963325,0.0001314301,0.0001313491,0.0008737231,0.0002755011,0.00954877],"genre_scores_gemma":[0.9939492,0.002398365,0.001778429,0.0000889096,0.00001671296,0.000052784,0.0006334618,0.0000172207,0.001064811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00124418,"threshold_uncertainty_score":0.004162192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01301276663784415,"score_gpt":0.253539296770557,"score_spread":0.2405265301327129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}