{"id":"W2118056343","doi":"10.1038/sj.embor.7400491","title":"Control of epidermal growth factor receptor endocytosis by receptor dimerization, rather than receptor kinase activation","year":2005,"lang":"en","type":"article","venue":"EMBO Reports","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":155,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale; Ariad Pharmaceuticals","keywords":"Endocytosis; Cell biology; Epidermal growth factor receptor; Receptor; Enzyme-linked receptor; Receptor-mediated endocytosis; Growth factor receptor; Insulin-like growth factor 1 receptor; Tropomyosin receptor kinase C; ERBB3; Biology; Epidermal growth factor; Co-receptor; Chemistry; Platelet-derived growth factor receptor; Signal transduction; Biochemistry; Growth factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005342369,0.000283595,0.0003116861,0.0001413054,0.0003219094,0.0008900469,0.0003064502,0.0004350012,0.002142662],"category_scores_gemma":[0.0003307585,0.0001831569,0.000333841,0.0001387063,0.0003031578,0.0007403871,0.0003785506,0.0007573972,0.0008242095],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005208051,"about_ca_system_score_gemma":0.0002127908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002649389,"about_ca_topic_score_gemma":0.0005043417,"domain_scores_codex":[0.99954,0.00009076401,0.00003124434,0.00009216546,0.00008577971,0.0001600778],"domain_scores_gemma":[0.9998253,0.00003554611,0.00004051032,0.0000305138,0.00002217296,0.00004593104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003005991,0.00004226195,0.0001740778,0.0000573483,0.00001051138,0.00008005719,0.00002906547,0.0001315693,0.9929455,0.002408505,0.0004647195,0.003355759],"study_design_scores_gemma":[0.00005767904,0.00008980119,0.003077435,0.000008169042,0.00001101912,0.0005261902,0.00007292344,0.003198669,0.9851443,0.0008902272,0.00691172,0.0000118261],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9593627,0.01220366,0.01385432,0.001913508,0.0004129733,0.00005445481,0.0003437064,0.0003388389,0.01151576],"genre_scores_gemma":[0.9916062,0.001453326,0.001751447,0.000268405,0.00004609417,0.00001508016,0.0001973098,0.00002904302,0.004633027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002142662,"threshold_uncertainty_score":0.007167935,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02054425572896974,"score_gpt":0.302996259354803,"score_spread":0.2824520036258332,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}