{"id":"W2118090969","doi":"10.4049/jimmunol.166.5.3491","title":"Oncostatin M-Induced Matrix Metalloproteinase and Tissue Inhibitor of Metalloproteinase-3 Genes Expression in Chondrocytes Requires Janus Kinase/STAT Signaling Pathway","year":2001,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":167,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Hôpital Notre-Dame","funders":"","keywords":"Oncostatin M; Janus kinase; Cell biology; JAK-STAT signaling pathway; Chemistry; Phosphorylation; Molecular biology; Signal transduction; Protein kinase A; Janus kinase 2; Kinase; STAT1; Janus kinase 3; Tyrosine kinase; Cancer research; Biology; Biochemistry; Cytokine; Immunology; Interleukin 6","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009343787,0.0002314777,0.0007156652,0.0004574465,0.000109896,0.0000170801,0.0001978158,0.0001374808,0.000192721],"category_scores_gemma":[0.0004175861,0.000148802,0.0001407067,0.0003064034,0.0001597077,0.0002428134,0.00009599423,0.0006144712,0.000005265167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008777113,"about_ca_system_score_gemma":0.0001558618,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003536484,"about_ca_topic_score_gemma":0.00004233976,"domain_scores_codex":[0.9978366,0.0003733386,0.001044756,0.0001653327,0.0002871051,0.0002927929],"domain_scores_gemma":[0.9981514,0.000354776,0.00080083,0.0002978587,0.0003088599,0.00008624151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002046996,0.0002431337,0.0002370479,0.00005174535,0.00015067,0.000344799,0.001205585,0.00005072826,0.9827919,0.00004282248,0.00002038397,0.01281421],"study_design_scores_gemma":[0.002313007,0.002657198,0.000999118,0.0007467939,0.0001555573,0.002564008,0.002274568,0.00002920334,0.9850805,0.0002077624,0.002838687,0.0001335618],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833798,0.01481619,0.0003597911,0.0006248238,0.0002899234,0.0004184547,0.000006560904,0.00001314597,0.00009133606],"genre_scores_gemma":[0.9957429,0.001234625,0.002575266,0.00004675238,0.0001715102,0.00001233071,0.000004203811,0.00002990265,0.0001825402],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01358157,"threshold_uncertainty_score":0.6067971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02519447646957225,"score_gpt":0.2974319796639561,"score_spread":0.2722375031943838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}