{"id":"W2118119162","doi":"10.1093/jac/dkt028","title":"Integrating pharmacokinetics, pharmacodynamics and MIC distributions to assess changing antimicrobial activity against clinical isolates of Pseudomonas aeruginosa causing infections in Canadian hospitals (CANWARD)","year":2013,"lang":"en","type":"article","venue":"Journal of Antimicrobial Chemotherapy","topic":"Antibiotics Pharmacokinetics and Efficacy","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Boniface Hospital; University of Manitoba","funders":"","keywords":"Cefepime; Meropenem; Colistin; Piperacillin; Amikacin; Medicine; Tazobactam; Piperacillin/tazobactam; Ciprofloxacin; Pharmacodynamics; Pseudomonas aeruginosa; Microbiology; Carbapenem; Antimicrobial; Pharmacology; Pharmacokinetics; Antibiotics; Imipenem; Biology; Antibiotic resistance; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001379573,0.0008230417,0.000631727,0.0007405455,0.0005992108,0.000966513,0.0007717516,0.0004858352,0.001461359],"category_scores_gemma":[0.003821585,0.00031692,0.0009689286,0.001065312,0.0003072705,0.0003375024,0.0004106712,0.0005092548,0.0001294964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01837754,"about_ca_system_score_gemma":0.01746811,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.942515,"about_ca_topic_score_gemma":0.9351889,"domain_scores_codex":[0.9992093,0.0001785714,0.0000311204,0.0001367878,0.0002951557,0.0001490691],"domain_scores_gemma":[0.9985439,0.0004997213,0.0002535716,0.00007074936,0.0005121398,0.0001200491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001426073,0.000237191,0.5043964,0.0004224048,0.001356722,0.0002406985,0.00037106,0.4317162,0.004875473,0.001612045,0.00290002,0.05044564],"study_design_scores_gemma":[0.000167763,0.0008989953,0.4931694,0.00006316393,0.0005759845,0.0003057677,0.0002668045,0.4936875,0.00309322,0.00102469,0.006628707,0.0001180972],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9783444,0.002211221,0.01088031,0.0005236857,0.0000158433,0.0001656056,0.003282653,0.0002051031,0.004371151],"genre_scores_gemma":[0.9911729,0.0005905422,0.005387391,0.00009766951,0.000005212844,0.00003117507,0.001629029,0.0000176246,0.001068453],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05748498,"threshold_uncertainty_score":0.133339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02006192670390591,"score_gpt":0.3329177426214719,"score_spread":0.312855815917566,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}