{"id":"W2118120337","doi":"10.1124/mol.110.064014","title":"Potassium Channel Block by a Tripartite Complex of Two Cationophilic Ligands and a Potassium Ion","year":2010,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Howard Hughes Medical Institute; National Institutes of Health; National Science Foundation","keywords":"Chemistry; Potassium channel; Docking (animal); Ion channel; Selectivity; Stereochemistry; Helix (gastropod); Molecule; Biophysics; Potassium; Ligand-gated ion channel; Crystallography; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000170164,0.0001671924,0.0001786924,0.00008898897,0.00008086995,0.00001203121,0.0001140817,0.0001807524,0.0000730587],"category_scores_gemma":[0.00002637861,0.0001733678,0.00007138578,0.000122108,0.0001597024,0.000005485511,0.00008280016,0.0001500883,0.000005800055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007469633,"about_ca_system_score_gemma":0.00004617582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001866273,"about_ca_topic_score_gemma":0.000007809977,"domain_scores_codex":[0.998996,0.00006524743,0.0002534338,0.0003430769,0.0001106292,0.0002315691],"domain_scores_gemma":[0.9993991,0.00001245017,0.0001396265,0.0001858727,0.0001374397,0.0001255359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001067892,0.0001161808,0.0001331195,0.00001529521,0.0000539849,0.000003216303,0.00004757645,0.0001275198,0.9881153,0.00009997127,0.01092891,0.0002521543],"study_design_scores_gemma":[0.00204859,0.0002243999,0.0005443254,0.000001744425,0.00004988324,0.00006012964,0.00001676715,0.002831098,0.9698662,0.00009009385,0.0240944,0.0001723337],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951361,0.0002461016,0.00149982,0.001316861,0.001126198,0.000261473,0.00004226553,0.0000189557,0.0003522031],"genre_scores_gemma":[0.9976061,0.00004546029,0.000103546,0.001033508,0.0004250931,0.00004837435,0.0003421452,0.00002385559,0.0003719476],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01824905,"threshold_uncertainty_score":0.7069733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01065182238729112,"score_gpt":0.2774474361882928,"score_spread":0.2667956138010016,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}