{"id":"W2118124054","doi":"10.1007/s00401-012-0958-8","title":"Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas","year":2012,"lang":"en","type":"review","venue":"Acta Neuropathologica","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1067,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Cancer Institute; Brain Tumour Charity; Stichting Kinderen Kankervrij; Cancer Research UK","keywords":"Medulloblastoma; Biology; Transcriptome; Oncology; Wnt signaling pathway; Bioinformatics; Genetics; Internal medicine; Gene; Medicine; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004071957,0.001222192,0.004078773,0.003344329,0.0001725879,0.00116169,0.0008580294,0.0005304479,0.0007976643],"category_scores_gemma":[0.003687187,0.0004501948,0.007080745,0.005005506,0.0001767455,0.0006190104,0.0006807263,0.0006156367,0.0001337765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006992199,"about_ca_system_score_gemma":0.001019849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001952565,"about_ca_topic_score_gemma":0.003500086,"domain_scores_codex":[0.9984974,0.0005926649,0.0002559892,0.0003576508,0.0002337698,0.00006249777],"domain_scores_gemma":[0.9977241,0.001384732,0.0004014004,0.0001884727,0.0002268637,0.00007448004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.006312639,0.00007362873,0.1556387,0.07325842,0.4213206,0.001032609,0.0002592129,0.002932873,0.004724423,0.0006322414,0.005968855,0.3278458],"study_design_scores_gemma":[0.0006061594,0.0005700454,0.21468,0.008227808,0.7434266,0.00277481,0.0002648607,0.001254292,0.002611206,0.001735428,0.0237355,0.0001131898],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.01590605,0.9824256,0.000646001,0.0001929128,0.00006118778,0.00001816309,0.0005083809,0.00001652482,0.0002252542],"genre_scores_gemma":[0.2649202,0.7293642,0.002477856,0.0002914225,0.0002279042,0.00008669114,0.002363015,0.00003014046,0.000238618],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.004078773,"threshold_uncertainty_score":0.0215348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.192348695141878,"score_gpt":0.3898768286216369,"score_spread":0.1975281334797589,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}