{"id":"W2118154035","doi":"10.1371/journal.ppat.1004321","title":"Identification of Anti-virulence Compounds That Disrupt Quorum-Sensing Regulated Acute and Persistent Pathogenicity","year":2014,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":274,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique; Armand Frappier Museum","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Shriners Hospitals for Children","keywords":"Regulon; Pseudomonas aeruginosa; Quorum sensing; Virulence; Multidrug tolerance; Microbiology; Biology; Pathogen; Antibiotic resistance; Antibiotics; Drug resistance; Human pathogen; Bacteria; Biofilm; Gene; Bacterial protein; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000135803,0.0004414216,0.0004097793,0.0003421284,0.0001267233,0.0002610412,0.0002829711,0.0003162002,0.001574006],"category_scores_gemma":[0.0001292886,0.0001538121,0.000204055,0.0001852406,0.0001629207,0.0001974957,0.0001593817,0.0005234725,0.0002999064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002479749,"about_ca_system_score_gemma":0.0003110601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005094609,"about_ca_topic_score_gemma":0.001725906,"domain_scores_codex":[0.9999303,0.0000100812,0.000005634472,0.00001188893,0.00002173131,0.00002045451],"domain_scores_gemma":[0.9999195,0.00001375456,0.0000214569,0.000005844491,0.00002082818,0.00001853567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001579511,0.0002069834,0.0002092929,0.0001141755,0.00001087109,0.00007287257,0.00001376566,0.0003989626,0.9890588,0.0002047777,0.0001887843,0.009362772],"study_design_scores_gemma":[0.0002744854,0.004890761,0.004713936,0.00003317175,0.0000648895,0.000544875,0.00003279073,0.001760704,0.9790552,0.0001195793,0.008493686,0.00001584619],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9787341,0.008455693,0.006116432,0.0003865735,0.00007435717,0.0003646436,0.0008728666,0.0001935934,0.004801703],"genre_scores_gemma":[0.9853194,0.005236171,0.004970189,0.0002026048,0.00002870632,0.0001013348,0.0009471006,0.00002119267,0.003173343],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001574006,"threshold_uncertainty_score":0.005265594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01272784778104823,"score_gpt":0.2203375765523992,"score_spread":0.2076097287713509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}