{"id":"W2118188679","doi":"","title":"The first structure of UDP-glucose dehydrogenase reveals the catalytic residues necessary for the two-fold oxidation.","year":2000,"lang":"en","type":"article","venue":"PubMed","topic":"Neonatal Health and Biochemistry","field":"Medicine","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"NAD+ kinase; Biochemistry; Chemistry; Active site; Ternary complex; Dehydrogenase; Asparagine; Oxidoreductase; Enzyme; Nicotinamide adenine dinucleotide; Stereochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004543837,0.0001318726,0.000168262,0.00001430444,0.0004428813,0.00002443697,0.0003226082,0.00007156205,0.00003759789],"category_scores_gemma":[0.0002681541,0.00005575593,0.00009804385,0.0001817308,0.0001941923,0.00004118491,0.00003051073,0.000179362,0.000003345385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004266829,"about_ca_system_score_gemma":0.00008336172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001026829,"about_ca_topic_score_gemma":0.0001915027,"domain_scores_codex":[0.9988133,0.00002502618,0.0003154842,0.0001889371,0.0002613751,0.0003959227],"domain_scores_gemma":[0.9983826,0.000663048,0.0001185814,0.0006251974,0.00008096384,0.0001296296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003784003,0.0001959815,0.005307083,0.001838163,0.0004072007,0.00002115827,0.0005886048,0.00004246969,0.01011105,0.0004774915,0.09637651,0.8808503],"study_design_scores_gemma":[0.002705542,0.00007976359,0.1640608,0.00008920016,0.0003536692,0.0001365861,0.0003328609,0.0001206493,0.6419114,0.001901476,0.1880806,0.0002275006],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9676297,0.01002694,0.000002727103,0.01932642,0.0001097075,0.002046863,0.0001405478,0.0000255595,0.0006915518],"genre_scores_gemma":[0.9935579,0.0005672355,0.0000257698,0.001988732,0.0004332641,0.0005438775,0.00006529015,0.00001673276,0.0028012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8806228,"threshold_uncertainty_score":0.340633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0143575736110617,"score_gpt":0.2542519483041693,"score_spread":0.2398943746931076,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}