{"id":"W2118196285","doi":"10.1128/aac.02813-14","title":"Tulathromycin Exerts Proresolving Effects in Bovine Neutrophils by Inhibiting Phospholipases and Altering Leukotriene B<sub>4</sub>, Prostaglandin E<sub>2</sub>, and Lipoxin A<sub>4</sub>Production","year":2014,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Microbial infections and disease research","field":"Immunology and Microbiology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Lipoxin; Proinflammatory cytokine; Lipid signaling; Eicosanoid; Leukotriene B4; Leukotriene; Inflammation; Phospholipase A2; Arachidonate 5-lipoxygenase; Zymosan; Chemistry; Arachidonic acid; Prostaglandin E; Bronchoalveolar lavage; Prostaglandin; Leukotriene C4; Pharmacology; Immunology; Biology; Biochemistry; Internal medicine; In vitro; Medicine; Lung; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001684615,0.0002707989,0.0003554937,0.0001569313,0.0001211731,0.0002429186,0.0002148972,0.0003634956,0.0005084455],"category_scores_gemma":[0.0001191868,0.00008435887,0.0002089187,0.000107684,0.0001958675,0.000195609,0.0001716411,0.0004153639,0.0001749617],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002380789,"about_ca_system_score_gemma":0.0002141659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008054149,"about_ca_topic_score_gemma":0.001774978,"domain_scores_codex":[0.9998438,0.00004136732,0.00002131455,0.00002759937,0.0000306055,0.00003520794],"domain_scores_gemma":[0.9999067,0.00002077181,0.00002807709,0.00001023401,0.00001077298,0.0000234716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001403045,0.00003462406,0.0001100159,0.00004437304,0.000002529996,0.00001736858,0.00000875188,0.00001654477,0.9981499,0.000009881362,0.0000104873,0.001455354],"study_design_scores_gemma":[0.00004573529,0.001858896,0.007074814,0.00001146095,0.00003060828,0.0001633241,0.00003150498,0.0005761347,0.9882115,0.00001909324,0.001970537,0.000006452974],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890909,0.007769636,0.001925012,0.0001237006,0.00002510572,0.0000379191,0.0001975954,0.00005445415,0.0007757075],"genre_scores_gemma":[0.9926985,0.002970963,0.002541793,0.0001137051,0.00002390097,0.00002777174,0.0003212838,0.000009059449,0.001293004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008054149,"threshold_uncertainty_score":0.001727343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006858653269310255,"score_gpt":0.223300256472725,"score_spread":0.2164416032034147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}