{"id":"W2118216564","doi":"10.1158/1055-9965.epi-14-0398","title":"Downregulation of microRNAs 145-3p and 145-5p Is a Long-term Predictor of Postmenopausal Breast Cancer Risk: The ORDET Prospective Study","year":2014,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Population Health Research Institute; McMaster University; Hamilton Health Sciences","funders":"","keywords":"Breast cancer; Prospective cohort study; microRNA; Cancer; Oncology; Medicine; Metastasis; Internal medicine; Downregulation and upregulation; Cohort; Proportional hazards model; Cohort study; Bioinformatics; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001279711,0.0002727661,0.000379724,0.0005795838,0.0004219474,0.0009325631,0.0003656514,0.0004013589,0.0009537325],"category_scores_gemma":[0.001674384,0.0003001839,0.0004778653,0.001065481,0.0001975004,0.0002796062,0.0005433857,0.0004440067,0.0001972158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002317752,"about_ca_system_score_gemma":0.0002970364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00305892,"about_ca_topic_score_gemma":0.00392992,"domain_scores_codex":[0.9994571,0.0001478101,0.00006165725,0.0001562511,0.0001158643,0.00006148878],"domain_scores_gemma":[0.9988407,0.0002260618,0.0003865846,0.0002078133,0.0001495253,0.0001892773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001180418,0.00003216971,0.9963132,0.00001613445,0.0001069999,0.0001165947,0.00003832683,0.000026905,0.0009930219,0.00002043951,0.00007185691,0.001083846],"study_design_scores_gemma":[0.00004454719,0.0001426129,0.9982738,0.000008147885,0.0001781296,0.0003317303,0.00006150566,0.000128447,0.0003338224,0.00002237947,0.0004696858,0.000005170622],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976962,0.0007669711,0.0002302198,0.00003232638,0.00001007283,0.00001252269,0.0009019215,0.00000428842,0.0003454213],"genre_scores_gemma":[0.9976513,0.0002812994,0.0003432261,0.0000342955,0.00001460711,0.00001754957,0.001310601,0.00000520591,0.0003418795],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00305892,"threshold_uncertainty_score":0.006767869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01300188773443201,"score_gpt":0.3132773536609608,"score_spread":0.3002754659265288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}