{"id":"W2118228232","doi":"10.1186/s12885-015-1421-8","title":"Targeted deep sequencing of mucinous ovarian tumors reveals multiple overlapping RAS-pathway activating mutations in borderline and cancerous neoplasms","year":2015,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":149,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"BC Cancer Foundation; VGH and UBC Hospital Foundation","keywords":"KRAS; CDKN2A; PTEN; Cancer research; STK11; Biology; Ovarian cancer; Mucinous carcinoma; Massive parallel sequencing; Genetic heterogeneity; Exome sequencing; Cancer; Adenocarcinoma; Mutation; DNA sequencing; Gene; Colorectal cancer; Genetics; PI3K/AKT/mTOR pathway; Phenotype; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002635058,0.0002192712,0.0005423268,0.0001822716,0.00006495605,0.00001882995,0.00005711666,0.00008880957,0.00005989023],"category_scores_gemma":[0.000485727,0.0002037848,0.00006079133,0.0004494204,0.00005354557,0.0001415097,0.00003921454,0.0001715707,0.000001760439],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001444403,"about_ca_system_score_gemma":0.001307199,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.02400666,"about_ca_topic_score_gemma":0.02129414,"domain_scores_codex":[0.9984052,0.00006314433,0.0005067429,0.0004016673,0.0002777409,0.0003455456],"domain_scores_gemma":[0.9988097,0.0002204905,0.0002652149,0.0002511454,0.0002389349,0.0002145181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004524984,0.0002557463,0.9376005,0.0004361126,0.0001776947,0.0001161868,0.008530105,0.01359425,0.01512277,0.0001471135,0.0001789524,0.0233881],"study_design_scores_gemma":[0.02463049,0.0008572327,0.8911837,0.003414812,0.0002884173,0.0001602327,0.008706397,0.03555442,0.03257912,0.0004081592,0.001397219,0.0008197529],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936888,0.003573514,0.0006631233,0.0004743254,0.0002303043,0.0007460623,0.0000658397,0.00004589846,0.0005121052],"genre_scores_gemma":[0.9898577,0.0001263873,0.009062861,0.0002546955,0.0001941495,0.0002926681,0.00003954332,0.0000388345,0.0001331281],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04641672,"threshold_uncertainty_score":0.9965647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04550892229067718,"score_gpt":0.2958274871775814,"score_spread":0.2503185648869043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}