{"id":"W2118231021","doi":"10.1139/y09-094","title":"Leflunomide induces immunosuppression in collagen-induced arthritis rats by upregulating CD4<sup>+</sup>CD25<sup>+</sup>regulatory T cells","year":2010,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Science and Technology of China; National Science Foundation","keywords":"IL-2 receptor; Leflunomide; FOXP3; Arthritis; Flow cytometry; Endocrinology; Cytokine; Chemistry; Internal medicine; Spleen; Concanavalin A; Molecular biology; Immunology; In vitro; Medicine; Biology; T cell; Immune system; Rheumatoid arthritis; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009619153,0.0004956434,0.0004158974,0.0003518618,0.0001376531,0.0001791077,0.0001395822,0.0002701032,0.001022627],"category_scores_gemma":[0.00008403305,0.0001391696,0.0002335601,0.0001298083,0.0002355269,0.000192965,0.00008064892,0.0006365397,0.0002153028],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001634215,"about_ca_system_score_gemma":0.0001804866,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005549394,"about_ca_topic_score_gemma":0.001118254,"domain_scores_codex":[0.9999013,0.00002168563,0.000008670055,0.00001365628,0.00001929941,0.00003540104],"domain_scores_gemma":[0.9998844,0.00001607693,0.00003888697,0.000009885023,0.00001053289,0.0000402652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006149243,0.0001532491,0.000178159,0.00003785026,0.000005417827,0.00006414208,0.00000859341,0.0000344372,0.9968708,0.00001900551,0.00002886614,0.001984525],"study_design_scores_gemma":[0.0001280017,0.004342363,0.00537736,0.000007730943,0.0000382063,0.0002130521,0.0000362079,0.0003394989,0.9883697,0.0000348892,0.001105917,0.000007143431],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966382,0.001728619,0.00061494,0.00006597723,0.00002640017,0.00001990191,0.0001191788,0.00005741157,0.000729382],"genre_scores_gemma":[0.9953979,0.001425541,0.001215796,0.00007054563,0.00003135714,0.00003725536,0.0002182874,0.00001352001,0.001589786],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001022627,"threshold_uncertainty_score":0.003421068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008771893961934158,"score_gpt":0.2282510062602672,"score_spread":0.2194791122983331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}