{"id":"W2118238803","doi":"10.1016/j.ccr.2010.04.027","title":"Regression of Castrate-Recurrent Prostate Cancer by a Small-Molecule Inhibitor of the Amino-Terminus Domain of the Androgen Receptor","year":2010,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":508,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Transactivation; Androgen receptor; Prostate cancer; Androgen; Cancer research; Receptor; Small molecule; Androgen Receptor Antagonists; Endocrinology; Biology; Internal medicine; Chemistry; Gene; Medicine; Cancer; Transcription factor; Biochemistry; Hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001413274,0.0001840677,0.0003318199,0.00002978451,0.00006640064,0.000005739902,0.0002538008,0.0001053699,0.0002987857],"category_scores_gemma":[0.00001555968,0.00008683564,0.0001718579,0.0002519216,0.0004231814,0.00003498164,0.0001209363,0.0002932199,0.000001265198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001378201,"about_ca_system_score_gemma":0.0007261244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001089616,"about_ca_topic_score_gemma":0.0006474162,"domain_scores_codex":[0.9986558,0.00007092784,0.0003509911,0.0002489878,0.0003951306,0.0002781819],"domain_scores_gemma":[0.9987918,0.00002946475,0.0003444954,0.0004916838,0.0002377123,0.0001048453],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005750002,0.0002422997,0.03097938,0.0005108818,0.00005244228,0.000003353136,0.001166352,0.000001219385,0.9536834,0.000004887377,0.006314258,0.006466485],"study_design_scores_gemma":[0.002154991,0.0002386748,0.003029461,0.0007216191,0.00008648176,0.000003385285,0.0002291957,0.00001039494,0.9875479,0.00001048076,0.005878406,0.00008900047],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875697,0.008566121,5.302339e-7,0.0006770549,0.0008144517,0.001019922,0.0005154976,0.00000684458,0.0008298811],"genre_scores_gemma":[0.9938853,0.001434244,0.00004541801,0.00003788922,0.0001066499,0.0001676189,0.00001681775,0.00002657887,0.004279416],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03386446,"threshold_uncertainty_score":0.3541054,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01518591805299086,"score_gpt":0.2911771918174362,"score_spread":0.2759912737644454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}