{"id":"W2118242699","doi":"10.1161/atvbaha.115.306032","title":"PCSK9 Induces CD36 Degradation and Affects Long-Chain Fatty Acid Uptake and Triglyceride Metabolism in Adipocytes and in Mouse Liver","year":2015,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":226,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute","funders":"Canadian Institutes of Health Research; Institut de Cardiologie de Montréal; Université du Québec à Montréal","keywords":"CD36; PCSK9; Triglyceride; Endocrinology; Internal medicine; LDL receptor; Fatty acid; Biology; Lipoprotein; Proprotein convertase; Kexin; Scavenger receptor; Fatty acid metabolism; Lipid metabolism; Chemistry; Biochemistry; Cholesterol; Receptor; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002487836,0.0006966302,0.0003902153,0.0006922936,0.0003220933,0.0004206897,0.0002767396,0.0006143671,0.002500716],"category_scores_gemma":[0.0001159869,0.0004321424,0.0007814003,0.0004036135,0.0006465135,0.0003118936,0.0003237675,0.001402081,0.001030285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008181156,"about_ca_system_score_gemma":0.0002963891,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001482389,"about_ca_topic_score_gemma":0.002074161,"domain_scores_codex":[0.9995534,0.00004559064,0.00005763538,0.0001291706,0.000111476,0.0001026564],"domain_scores_gemma":[0.9997134,0.00003002748,0.00009802152,0.00004291212,0.00002377944,0.00009187227],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003005386,0.00003231719,0.0001416599,0.00002907691,0.000007478674,0.00006185761,0.00001342176,0.00004449016,0.9988651,0.00006038176,0.00002867779,0.0004150019],"study_design_scores_gemma":[0.00002845206,0.0001695647,0.002887292,0.000004733194,0.00001671343,0.0001666011,0.0000242095,0.0003932644,0.995408,0.00003173914,0.0008654317,0.000004033724],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881011,0.001617914,0.005105969,0.000289412,0.00009289132,0.00007724277,0.002287939,0.0003736686,0.002053628],"genre_scores_gemma":[0.9804267,0.001313996,0.004324968,0.000128055,0.00001707797,0.0001238307,0.001835054,0.0001201922,0.01171012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002500716,"threshold_uncertainty_score":0.008365691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04856876130557718,"score_gpt":0.279089592920953,"score_spread":0.2305208316153758,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}