{"id":"W2118283685","doi":"10.1158/1535-7163.mct-09-0478","title":"Inhibition of Y-box binding protein-1 slows the growth of glioblastoma multiforme and sensitizes to temozolomide independent <i>O</i> 6-methylguanine-DNA methyltransferase","year":2009,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; McGill University; University of British Columbia; Montreal Children's Hospital; BC Cancer Agency","funders":"C17 Council; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Temozolomide; Methyltransferase; Cancer research; Medicine; Glioblastoma; O-6-methylguanine-DNA methyltransferase; Cancer; Brain tumor; Internal medicine; Oncology; Gene; Biology; Pathology; Methylation; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001999861,0.0002272292,0.0004010502,0.0001721037,0.00006146316,0.0000147021,0.00006435619,0.00009707169,0.000009526013],"category_scores_gemma":[0.0000186149,0.0001577644,0.0001402287,0.0003620766,0.0000797654,0.00003966704,0.00002302367,0.0001375988,0.000001739404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007525383,"about_ca_system_score_gemma":0.00006743241,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001097293,"about_ca_topic_score_gemma":0.00003880553,"domain_scores_codex":[0.9986554,0.00006444565,0.0003761964,0.0002639423,0.0003962491,0.0002437161],"domain_scores_gemma":[0.9992417,0.00004752575,0.0001248252,0.000279125,0.0001985995,0.0001083026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004635824,0.0002759122,0.0009212868,0.00006706805,0.0002928201,0.0000840845,0.0007464483,0.00002505567,0.985967,0.0003539539,0.000006396889,0.01079643],"study_design_scores_gemma":[0.002255998,0.001267739,0.001914016,0.0002815722,0.0004764423,0.00003260849,0.0001770746,0.00004195354,0.9931381,0.0001946111,0.00007602521,0.0001438152],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931461,0.001176607,0.0005769476,0.003717647,0.00003786715,0.001206824,0.00005037885,0.00002411403,0.00006350716],"genre_scores_gemma":[0.9969893,0.000229363,0.001068041,0.001567265,0.00002513298,0.00007579736,0.000006990666,0.00002741584,0.00001075493],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01065262,"threshold_uncertainty_score":0.6433445,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01375698992982216,"score_gpt":0.2704361288399778,"score_spread":0.2566791389101556,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}