{"id":"W2118295898","doi":"10.4049/jimmunol.1001512","title":"Cutting Edge: Proteolytic Inactivation of Poly(ADP-Ribose) Polymerase 1 by the Nlrp3 and Nlrc4 Inflammasomes","year":2010,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":137,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Takeda Oncology; National Cancer Institute; Yale University; National Institutes of Health; American Lebanese Syrian Associated Charities; National Institute of Allergy and Infectious Diseases; Vlaamse regering","keywords":"Inflammasome; Pyroptosis; NLRC4; Poly ADP ribose polymerase; AIM2; Caspase 1; Cell biology; PARP1; Apoptosis; Caspase; NLRP1; Chemistry; Programmed cell death; Biology; Polymerase; Molecular biology; Biochemistry; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005852969,0.0004412937,0.000400519,0.000155048,0.0001436153,0.0006419959,0.0004223307,0.0009130156,0.002309375],"category_scores_gemma":[0.0004990503,0.0001614155,0.0003881144,0.0001789118,0.0003928688,0.0008435988,0.0003476791,0.001035427,0.001024183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003060186,"about_ca_system_score_gemma":0.0001989609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007000269,"about_ca_topic_score_gemma":0.00005247703,"domain_scores_codex":[0.9995723,0.00008129812,0.00006743593,0.00007269352,0.0001390559,0.00006712384],"domain_scores_gemma":[0.9995781,0.00005384897,0.0001737098,0.0000583498,0.00006376114,0.00007226572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001292246,0.00008540116,0.001208639,0.0007073111,0.0000579647,0.0005523558,0.0000446722,0.0002155992,0.9685125,0.002758177,0.001225554,0.02333958],"study_design_scores_gemma":[0.0001603502,0.0009568079,0.0146348,0.00007303775,0.00006858128,0.007809596,0.00007037456,0.001129413,0.9533591,0.00274897,0.01897207,0.00001692328],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8663039,0.08857442,0.02473854,0.009301984,0.001155356,0.0001123915,0.001352892,0.000517134,0.007943292],"genre_scores_gemma":[0.9673712,0.01686808,0.00776069,0.001549894,0.0004372106,0.00005142296,0.0008988887,0.00003726408,0.005025408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002309375,"threshold_uncertainty_score":0.007725656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00333091661709219,"score_gpt":0.2126573262874219,"score_spread":0.2093264096703297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}