{"id":"W2118295898","doi":"10.4049/jimmunol.1001512","title":"Cutting Edge: Proteolytic Inactivation of Poly(ADP-Ribose) Polymerase 1 by the Nlrp3 and Nlrc4 Inflammasomes","year":2010,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":137,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Takeda Oncology; National Cancer Institute; Yale University; National Institutes of Health; American Lebanese Syrian Associated Charities; National Institute of Allergy and Infectious Diseases; Vlaamse regering","keywords":"Inflammasome; Pyroptosis; NLRC4; Poly ADP ribose polymerase; AIM2; Caspase 1; Cell biology; PARP1; Apoptosis; Caspase; NLRP1; Chemistry; Programmed cell death; Biology; Polymerase; Molecular biology; Biochemistry; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006090144,0.0001283368,0.0001803256,0.00005526829,0.0001507757,0.00001318484,0.0003550976,0.0001480354,0.00001836325],"category_scores_gemma":[0.0003208227,0.00007459568,0.00007417017,0.00008330862,0.0004005008,0.00001585569,0.0001230659,0.0004243628,0.000001529665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006202359,"about_ca_system_score_gemma":0.00009811992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005196878,"about_ca_topic_score_gemma":0.00000859878,"domain_scores_codex":[0.9990662,0.0001615007,0.0003950553,0.00008399913,0.00009909111,0.0001941718],"domain_scores_gemma":[0.9989135,0.00007547403,0.0005321307,0.0002984008,0.00015945,0.00002106644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003024489,0.00003342643,0.0006326452,0.000006971812,0.0001438147,6.998854e-7,0.0003294006,0.000001549907,0.9801179,0.00007490722,0.0004121727,0.01794408],"study_design_scores_gemma":[0.0008091663,0.000477065,0.006384691,0.00001369929,0.00004830238,0.0002918488,0.0008413146,0.000006856425,0.9806454,0.0001485278,0.01024192,0.00009127318],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889409,0.008491661,0.0001167903,0.0018039,0.0002700976,0.000143054,0.000002657559,0.00000236894,0.0002285616],"genre_scores_gemma":[0.9986616,0.000702549,0.00006213394,0.0001466059,0.0001737705,0.0000037123,0.000005980161,0.00001413606,0.000229524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01785281,"threshold_uncertainty_score":0.3041923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00333091661709219,"score_gpt":0.2126573262874219,"score_spread":0.2093264096703297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}