{"id":"W2118362648","doi":"10.1186/1471-2474-14-27","title":"Subchondral pre-solidified chitosan/blood implants elicit reproducible early osteochondral wound-repair responses including neutrophil and stromal cell chemotaxis, bone resorption and repair, enhanced repair tissue integration and delayed matrix deposition","year":2013,"lang":"en","type":"article","venue":"BMC Musculoskeletal Disorders","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; McGill University Health Centre; Montreal General Hospital; Piramal (Canada); Polytechnique Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Canadian Arthritis Network; Fonds Québécois de la Recherche sur la Nature et les Technologies","keywords":"Stromal cell; Medicine; Resorption; Bone marrow; Bone resorption; Pathology; Implant; Demineralized bone matrix; Cartilage; Bone remodeling; Chitosan; Biomedical engineering; Anatomy; Surgery; Materials science; Chemistry; Internal medicine; dBm","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002883941,0.0005569716,0.0006114265,0.0003435602,0.0004122168,0.0001379386,0.00006937304,0.0003403004,0.00003153312],"category_scores_gemma":[0.0002227471,0.0005270296,0.0002823689,0.0002883554,0.0001818774,0.0008216763,0.0001565114,0.0003496909,0.00001301104],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005499058,"about_ca_system_score_gemma":0.00007207115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001111031,"about_ca_topic_score_gemma":0.0009757957,"domain_scores_codex":[0.9967233,0.0002565482,0.000679434,0.001295326,0.0004189796,0.0006264216],"domain_scores_gemma":[0.9985108,0.0001383135,0.0002619466,0.0006405585,0.0001002941,0.0003480263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002226651,0.0003353535,0.01693179,0.0005947076,0.0000853228,0.00002724548,0.0009946862,0.000001256351,0.9725459,0.00008634897,0.00007059805,0.006100123],"study_design_scores_gemma":[0.01980834,0.02084036,0.4944824,0.0008101156,0.001582515,0.000715133,0.002065887,0.0007286227,0.4566531,0.0006802023,0.00008770465,0.001545697],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929278,0.002657222,0.0003067538,0.0001923849,0.0002031211,0.002625783,0.00003242581,0.0007531244,0.0003013412],"genre_scores_gemma":[0.9854754,0.0008903932,0.01189701,0.00004307395,0.0001920687,0.0002978783,0.0002991942,0.00008644425,0.0008185962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5158929,"threshold_uncertainty_score":0.9997181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009666944134519554,"score_gpt":0.2646484702838636,"score_spread":0.254981526149344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}