{"id":"W2118365019","doi":"10.1074/jbc.m210840200","title":"Effect of Glycosylphosphatidylinositol Anchor-dependent and -independent Prion Protein Association with Model Raft Membranes on Conversion to the Protease-resistant Isoform","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":117,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Raft; Gene isoform; Prion protein; Membrane; Protease; Chemistry; Cell biology; Association (psychology); Biophysics; Biochemistry; Biology; Enzyme; Medicine; Gene; Psychology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003406116,0.0004342191,0.0002713323,0.000111923,0.0001747412,0.0003202589,0.0003324702,0.0002967395,0.0008638531],"category_scores_gemma":[0.000362089,0.0002115246,0.0002661435,0.0001656893,0.0002192486,0.0002287011,0.0003178707,0.0006149116,0.0003748148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002522235,"about_ca_system_score_gemma":0.0001982906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001017039,"about_ca_topic_score_gemma":0.00108766,"domain_scores_codex":[0.9996687,0.0001460725,0.00003380837,0.00004017804,0.00006496064,0.00004624764],"domain_scores_gemma":[0.9996463,0.0001451882,0.00006516196,0.00004521288,0.0000357115,0.00006233947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005569475,0.0001243449,0.0001867631,0.0000498849,0.00001890898,0.0001188666,0.00003543903,0.00007893529,0.998127,0.00005630426,0.00003218991,0.0006143042],"study_design_scores_gemma":[0.00003384746,0.0005804817,0.002176889,0.000006198589,0.00001706363,0.0001659484,0.00002301202,0.001044998,0.9952309,0.0000173483,0.0006962883,0.000007153213],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985233,0.0005502257,0.0002933312,0.00003482588,0.00001203608,0.00001467347,0.00009805714,0.00001275998,0.0004608787],"genre_scores_gemma":[0.9973017,0.0005251018,0.0009208875,0.00003145669,0.000008114482,0.00001844425,0.000330199,0.00001373141,0.0008504217],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001017039,"threshold_uncertainty_score":0.002889872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006736507855683531,"score_gpt":0.2296559977242256,"score_spread":0.2229194898685421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}