{"id":"W2118385994","doi":"10.1158/1078-0432.ccr-14-2352","title":"ERG/AKR1C3/AR Constitutes a Feed-Forward Loop for AR Signaling in Prostate Cancer Cells","year":2015,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Aldose Reductase and Taurine","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Center for Research Resources; National Cancer Institute; National Institutes of Health","keywords":"Prostate cancer; Prostate; Cancer; Cancer research; Erg; Internal medicine; Biology; Oncology; Medicine; Neuroscience; Retina","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002355436,0.0001664405,0.0003197146,0.00008628496,0.000102854,0.0000442497,0.0003157902,0.0002083775,0.00005245428],"category_scores_gemma":[0.0005785118,0.0001461357,0.0001272963,0.0002323908,0.0004734778,0.000009056058,0.0002278207,0.0004320816,0.0000311608],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000876554,"about_ca_system_score_gemma":0.001999483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005563363,"about_ca_topic_score_gemma":0.0009565122,"domain_scores_codex":[0.9976031,0.0002074277,0.0005372855,0.0006254026,0.000358411,0.0006683894],"domain_scores_gemma":[0.9985059,0.0001643375,0.0000852255,0.0003555654,0.0005365098,0.000352425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008169129,0.001463173,0.0860937,0.0007199355,0.0007279639,0.0001658112,0.0005383705,0.00308105,0.6891752,0.0003963714,0.1347225,0.07474671],"study_design_scores_gemma":[0.003825835,0.0008186526,0.0003385756,0.0001579949,0.00002410141,0.000002922581,0.0002713008,0.0001802675,0.5901102,0.0004484594,0.4034721,0.0003494982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896634,0.007598535,0.00006954799,0.0008577305,0.0004178143,0.0008004856,0.00012081,0.00001186793,0.0004598082],"genre_scores_gemma":[0.9916694,0.002838427,0.0004561486,0.0002935891,0.001322108,0.0006660959,0.00009050803,0.00003983729,0.002623912],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2687496,"threshold_uncertainty_score":0.5959243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2209504148459641,"score_gpt":0.5114372484737918,"score_spread":0.2904868336278277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}