{"id":"W2118399321","doi":"10.1128/aac.46.7.2254-2256.2002","title":"Pressure of Zidovudine Accelerates the Reversion of Lamivudine Resistance-Conferring M184V Mutation in the Reverse Transcriptase of Human Immunodeficiency Virus Type 1","year":2002,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Reversion; Resistance mutation; Zidovudine; Reverse transcriptase; Virology; Lamivudine; Mutation; Reverse-transcriptase inhibitor; Virus; Biology; Sida; Genetics; Viral disease; RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001196023,0.0001715092,0.0001977878,0.0001398534,0.0001542082,0.0003846788,0.0002206131,0.0002067873,0.00112997],"category_scores_gemma":[0.0004261224,0.0001706743,0.0002114218,0.0001226705,0.0001350063,0.0001739295,0.0001528613,0.0003894499,0.0002311758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002552847,"about_ca_system_score_gemma":0.0001356198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001329879,"about_ca_topic_score_gemma":0.00202353,"domain_scores_codex":[0.9998369,0.00003533239,0.0000137634,0.00001812373,0.0000503731,0.00004551745],"domain_scores_gemma":[0.9998686,0.0000518018,0.00002281964,0.00001988589,0.00001815268,0.00001880213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002145661,0.00006980007,0.0007289232,0.00002532957,0.000009628206,0.0001276615,0.00003688012,0.00008506807,0.9957216,0.0001914528,0.00009330647,0.002695694],"study_design_scores_gemma":[0.0000647177,0.000847787,0.01230758,0.000005773355,0.00002273662,0.0003673301,0.00005304665,0.001591195,0.9813203,0.00005569169,0.003356865,0.0000070243],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985209,0.0005049264,0.0002689642,0.00006077499,0.0000210096,0.00000826466,0.00007758205,0.00001149454,0.0005260778],"genre_scores_gemma":[0.9978406,0.0003476643,0.0006376919,0.0000329109,0.00001620402,0.000008166578,0.0002275244,0.00001019129,0.0008789672],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001329879,"threshold_uncertainty_score":0.003780186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03060800966477378,"score_gpt":0.2672358188059311,"score_spread":0.2366278091411573,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}