{"id":"W2118416891","doi":"10.1093/carcin/bgu181","title":"Synergistic effects of combined DNA methyltransferase inhibition and MBD2 depletion on breast cancer cells; MBD2 depletion blocks 5-aza-2ʹ-deoxycytidine-triggered invasiveness","year":2014,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Canadian Institutes of Health Research; GlaxoSmithKline","keywords":"DNA methylation; Gene silencing; Methyltransferase; Cancer research; DNA methyltransferase; DNMT1; Methylation; Chemistry; Cell growth; Breast cancer; Cancer cell; In vitro; Biology; DNA; Cancer; Gene; Gene expression; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003209758,0.0003181821,0.000372145,0.0001562137,0.0001420448,0.00002560403,0.000111219,0.0002982111,0.00001372487],"category_scores_gemma":[0.0001285007,0.0003184949,0.0001433007,0.0001987752,0.0001144463,0.0000103228,0.00005300048,0.00008915573,0.000003126904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004625804,"about_ca_system_score_gemma":0.00007068829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002248663,"about_ca_topic_score_gemma":0.00008299616,"domain_scores_codex":[0.9981474,0.0003112955,0.0003879151,0.0005935866,0.0002632854,0.0002965181],"domain_scores_gemma":[0.9988284,0.0001419153,0.0001804651,0.0004260443,0.0002603383,0.0001628262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000310107,0.0001270511,0.006995933,0.0002972462,0.00007058872,0.000002699502,0.00003696665,0.0004073665,0.9874814,0.00008598544,0.00005101268,0.004133672],"study_design_scores_gemma":[0.001612608,0.0006531571,0.04133268,0.0001284957,0.0002224043,0.000002691158,0.00001172423,0.0002915559,0.9551061,0.0001469451,0.0001597654,0.0003318402],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884305,0.001544704,0.008946382,0.0001210884,0.0003161502,0.0004699999,0.00008673245,0.00002072909,0.00006368793],"genre_scores_gemma":[0.997538,0.001500282,0.0001241622,0.0001344928,0.0002433794,0.0001078241,0.0002648477,0.00005404048,0.00003297998],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03433675,"threshold_uncertainty_score":0.9999267,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006260765792800977,"score_gpt":0.2175300623542065,"score_spread":0.2112692965614055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}