{"id":"W2118416891","doi":"10.1093/carcin/bgu181","title":"Synergistic effects of combined DNA methyltransferase inhibition and MBD2 depletion on breast cancer cells; MBD2 depletion blocks 5-aza-2ʹ-deoxycytidine-triggered invasiveness","year":2014,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Canadian Institutes of Health Research; GlaxoSmithKline","keywords":"DNA methylation; Gene silencing; Methyltransferase; Cancer research; DNA methyltransferase; DNMT1; Methylation; Chemistry; Cell growth; Breast cancer; Cancer cell; In vitro; Biology; DNA; Cancer; Gene; Gene expression; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001042622,0.0003930964,0.0004912047,0.0002345011,0.0001173689,0.0002177924,0.0002338257,0.0002257629,0.001005671],"category_scores_gemma":[0.00007859452,0.0001608092,0.0002004488,0.0001411849,0.0001644106,0.0001161098,0.0002478725,0.0005059909,0.0002557964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001876601,"about_ca_system_score_gemma":0.0002560252,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006744087,"about_ca_topic_score_gemma":0.001716005,"domain_scores_codex":[0.9998628,0.00002457652,0.00001231851,0.00003045473,0.00003634493,0.00003356141],"domain_scores_gemma":[0.9999334,0.00001356557,0.00001042122,0.000009898941,0.000005491199,0.00002734883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000336687,0.00007208378,0.0001873273,0.00005652608,0.00001790808,0.00004410732,0.00001202047,0.0001233505,0.9968789,0.00005966411,0.00008261829,0.002128782],"study_design_scores_gemma":[0.00003918874,0.0005724785,0.002210322,0.00000313132,0.00002751931,0.0001207387,0.00001264128,0.0004954346,0.9935581,0.0000167199,0.00294004,0.000003745031],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910498,0.003970332,0.001814985,0.0001109497,0.00007517337,0.00006010194,0.0005515164,0.00009679312,0.002270424],"genre_scores_gemma":[0.9946477,0.001314136,0.00147649,0.00003749572,0.00001902328,0.00006915658,0.0004016944,0.00001231028,0.002022073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001005671,"threshold_uncertainty_score":0.003364325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006260765792800977,"score_gpt":0.2175300623542065,"score_spread":0.2112692965614055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}