{"id":"W2118430013","doi":"10.1128/mcb.25.9.3831-3841.2005","title":"Dok-R Mediates Attenuation of Epidermal Growth Factor-Dependent Mitogen-Activated Protein Kinase and Akt Activation through Processive Recruitment of c-Src and Csk","year":2005,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Heart and Stroke Foundation; University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Proto-oncogene tyrosine-protein kinase Src; Tyrosine-protein kinase CSK; Protein kinase B; Biology; Cell biology; Epidermal growth factor; SH3 domain; Tyrosine kinase; MAPK/ERK pathway; Src family kinase; Phosphorylation; Cancer research; Molecular biology; Signal transduction; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001840526,0.0001517439,0.0003257261,0.00009433326,0.00003940862,0.000006398535,0.00004747271,0.0001723901,0.00002333229],"category_scores_gemma":[0.0001661154,0.0001249257,0.00003220821,0.0001144993,0.0002262161,0.00006494284,0.00006785696,0.000146588,7.452604e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004366503,"about_ca_system_score_gemma":0.00008831968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001567313,"about_ca_topic_score_gemma":0.000005134774,"domain_scores_codex":[0.9988157,0.0001612256,0.0002989296,0.0003264602,0.0001897475,0.0002078957],"domain_scores_gemma":[0.9993573,0.00004910989,0.0001652925,0.0001449128,0.0001950133,0.00008830271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002464639,0.00008139303,0.005271105,0.0003447104,0.00008558786,0.00001074162,0.0006593853,9.558951e-7,0.9811198,0.0003361955,0.000005501862,0.01183814],"study_design_scores_gemma":[0.001428242,0.0006728386,0.002110201,0.0001116122,0.00003806311,0.00001120519,0.0001461386,0.0000502467,0.9945162,0.0004639315,0.0003452256,0.0001061293],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927124,0.002962743,0.001913194,0.001090317,0.00002217576,0.001165212,0.00001994134,0.00001159504,0.0001024228],"genre_scores_gemma":[0.9986687,0.0002902681,0.0006486625,0.0001123131,0.00004292242,0.0001064871,0.00008024665,0.00001691964,0.00003349999],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01339634,"threshold_uncertainty_score":0.5094323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05038912150552269,"score_gpt":0.3366343023050747,"score_spread":0.286245180799552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}