{"id":"W2118524399","doi":"10.1038/mt.2015.49","title":"Complement Inhibition Prevents Oncolytic Vaccinia Virus Neutralization in Immune Humans and Cynomolgus Macaques","year":2015,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital; University Health Network; Ottawa Hospital; University of Ottawa","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Oncolytic virus; Vaccinia; Neutralization; Virology; Complement (music); Immune system; Virus; Biology; Immunology; Phenotype; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002785789,0.0002417979,0.0002137379,0.0002710802,0.0001850362,0.0002771858,0.0001293331,0.0002611901,0.001005431],"category_scores_gemma":[0.0003069768,0.00009343604,0.0001269787,0.00006491732,0.0002790332,0.0001344286,0.0001694313,0.0003311432,0.0001527847],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003407649,"about_ca_system_score_gemma":0.0002855261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002797748,"about_ca_topic_score_gemma":0.002827539,"domain_scores_codex":[0.9998485,0.00004426209,0.000006059614,0.00003022978,0.00002250254,0.00004834498],"domain_scores_gemma":[0.9999166,0.00002019938,0.00002168904,0.00001325641,0.00001058691,0.00001770196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001001451,0.000164498,0.001172671,0.00004006515,0.00001658431,0.0001145862,0.0001078514,0.00005187046,0.9904502,0.0004094859,0.0001490851,0.006321711],"study_design_scores_gemma":[0.0001918626,0.00807761,0.03171159,0.00004379522,0.00009362934,0.002108085,0.0001489217,0.00256048,0.9433149,0.0004586626,0.01127355,0.00001683212],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970625,0.001112146,0.000737918,0.00006697708,0.00001064679,0.00002402562,0.0000387061,0.00002377069,0.0009233278],"genre_scores_gemma":[0.9977831,0.0004124313,0.0005256059,0.00005106388,0.000008974489,0.00002810672,0.00008857571,0.000008336704,0.001093867],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002797748,"threshold_uncertainty_score":0.005562901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03465507095423146,"score_gpt":0.331131245081174,"score_spread":0.2964761741269425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}