{"id":"W2118524399","doi":"10.1038/mt.2015.49","title":"Complement Inhibition Prevents Oncolytic Vaccinia Virus Neutralization in Immune Humans and Cynomolgus Macaques","year":2015,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital; University Health Network; Ottawa Hospital; University of Ottawa","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Oncolytic virus; Vaccinia; Neutralization; Virology; Complement (music); Immune system; Virus; Biology; Immunology; Phenotype; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004205614,0.0001956771,0.0001785291,0.0001128593,0.00005296601,0.00004554143,0.0001456017,0.0001157676,0.00003378893],"category_scores_gemma":[0.00001332265,0.0002015065,0.00005744324,0.0001496041,0.00004765644,0.000008882786,0.00007872338,0.0001046995,0.00001053845],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006452939,"about_ca_system_score_gemma":0.00008797656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001171707,"about_ca_topic_score_gemma":0.000252074,"domain_scores_codex":[0.9985126,0.0002817462,0.0002837946,0.0003772507,0.0002405869,0.0003039791],"domain_scores_gemma":[0.999378,0.000005054945,0.00007318907,0.0003516668,0.0000763953,0.0001156776],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001439424,0.0001820291,0.0009713104,0.000008118662,0.00004773267,0.00002198393,0.0001966081,0.0001601354,0.9914963,0.00005807737,0.0001131944,0.005305081],"study_design_scores_gemma":[0.003564081,0.003301521,0.002694649,0.00002149839,0.000005510482,0.000008004805,0.00005337712,0.0001240228,0.985926,0.0005915787,0.003470489,0.0002393136],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938762,0.00430487,0.0006779508,0.0002189614,0.00004522066,0.0006227206,0.00001116761,0.00001707352,0.00022588],"genre_scores_gemma":[0.9975885,0.001205591,0.0001446432,0.0005131665,0.00005444967,0.00009142703,0.0002620076,0.0000441522,0.00009613666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005570351,"threshold_uncertainty_score":0.8217195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03465507095423146,"score_gpt":0.331131245081174,"score_spread":0.2964761741269425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}