{"id":"W2118526439","doi":"10.1021/bc900041f","title":"Synthesis of a Labeled RGD−Lipid, Its Incorporation into Liposomal Nanoparticles, and Their Trafficking in Cultured Endothelial Cells","year":2009,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Research Council Canada; Canadian Institutes of Health Research; National Science Council","keywords":"Chemistry; Internalization; Liposome; In vivo; Peptide; Umbilical vein; Conjugate; Avidity; Drug delivery; Biochemistry; Biophysics; In vitro; Cell; Antibody; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000329223,0.0002557478,0.0001594246,0.0001580795,0.0001561355,0.000210455,0.0002270801,0.0002457687,0.0007199147],"category_scores_gemma":[0.0001622117,0.0002013575,0.0001844703,0.0001736031,0.0001719138,0.000184102,0.0001397534,0.000371801,0.000434425],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004177676,"about_ca_system_score_gemma":0.0002932132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007838719,"about_ca_topic_score_gemma":0.0008888185,"domain_scores_codex":[0.9999013,0.00002065342,0.00001497191,0.00002704055,0.00002155532,0.0000144595],"domain_scores_gemma":[0.9999392,0.00001803485,0.00001244783,0.000009499035,0.00001076942,0.0000100984],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003613512,0.00001390168,0.00004208483,0.00002210832,0.000002163334,0.0000409182,0.00001822936,0.00012459,0.998435,0.0002310903,0.00001823188,0.001015578],"study_design_scores_gemma":[0.000006467398,0.00007634923,0.000174387,0.000002750401,0.000004288441,0.00005119913,0.000005274748,0.0006846737,0.9975878,0.00003670704,0.001367908,0.000002328197],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9449867,0.001960441,0.04838869,0.0001761515,0.00005828276,0.0002314205,0.0005135503,0.000190654,0.00349425],"genre_scores_gemma":[0.9592242,0.001396818,0.03244442,0.00007434126,0.00001068927,0.0002146459,0.0007518865,0.00005941615,0.005823817],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007838719,"threshold_uncertainty_score":0.003031135,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007696780890119986,"score_gpt":0.2137625550606765,"score_spread":0.2060657741705565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}