{"id":"W2118526439","doi":"10.1021/bc900041f","title":"Synthesis of a Labeled RGD−Lipid, Its Incorporation into Liposomal Nanoparticles, and Their Trafficking in Cultured Endothelial Cells","year":2009,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Research Council Canada; Canadian Institutes of Health Research; National Science Council","keywords":"Chemistry; Internalization; Liposome; In vivo; Peptide; Umbilical vein; Conjugate; Avidity; Drug delivery; Biochemistry; Biophysics; In vitro; Cell; Antibody; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001163513,0.0001909596,0.0002099694,0.00002490245,0.00003856803,0.00002431926,0.0001568189,0.0002007139,0.00001128756],"category_scores_gemma":[0.00004751412,0.0001684076,0.00006223487,0.00008404293,0.00006476296,0.00001002877,0.00004637724,0.00007591207,0.000003161522],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001533487,"about_ca_system_score_gemma":0.00005361516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001387257,"about_ca_topic_score_gemma":0.00001658744,"domain_scores_codex":[0.9990565,0.00003161053,0.0003023289,0.0003373625,0.00007449881,0.0001976919],"domain_scores_gemma":[0.9995142,0.00001278659,0.0001302007,0.0002040279,0.00007048241,0.00006834233],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001745727,0.00009588547,0.0001988813,0.00005444386,0.00002467519,0.00000288509,0.0001884006,0.00001950588,0.9954727,0.000005617395,0.00008884673,0.003673532],"study_design_scores_gemma":[0.0004999072,0.000126222,0.0001768651,0.0000654648,0.00001294076,0.000008811592,0.0002020263,0.0001171875,0.9980818,0.0000442526,0.0004738747,0.0001906212],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986045,0.0008393824,0.00001705556,0.00009639518,0.00003666003,0.0001316894,0.00003538298,0.00001208302,0.0002268061],"genre_scores_gemma":[0.9991189,0.0002895813,0.0001969463,0.00009831443,0.0001330681,0.00001650225,0.00003870817,0.00001132465,0.00009667507],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00348291,"threshold_uncertainty_score":0.6867461,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007696780890119986,"score_gpt":0.2137625550606765,"score_spread":0.2060657741705565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}