{"id":"W2118544138","doi":"10.1101/gr.2946205","title":"Gene conversion and evolution of Xq28 duplicons involved in recurring inversions causing severe hemophilia A","year":2005,"lang":"en","type":"article","venue":"Genome Research","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Thomas Hospital","funders":"Medical Research Council; Hospital for Sick Children; King's College London","keywords":"Gene conversion; Biology; Xq28; Genetics; Gene; Haplotype; Concerted evolution; Breakpoint; Molecular evolution; Non-allelic homologous recombination; X chromosome; Recombination; Chromosomal inversion; Chromosome; Sequence (biology); Gene duplication; Phylogenetics; Karyotype; Allele; Genetic recombination","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002057142,0.0002992232,0.0002513243,0.001153323,0.000343462,0.0004082762,0.0002096685,0.0004101207,0.00113251],"category_scores_gemma":[0.0004993874,0.0001705822,0.0001912684,0.0007380283,0.0002958434,0.0001290352,0.0003457122,0.0003504431,0.0003104299],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002307077,"about_ca_system_score_gemma":0.0001107634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008322257,"about_ca_topic_score_gemma":0.001017174,"domain_scores_codex":[0.9998313,0.00003302248,0.00001375366,0.00004916272,0.00003581631,0.00003704993],"domain_scores_gemma":[0.9997092,0.00009102472,0.00008086074,0.00002237594,0.0000228447,0.00007362925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001056077,0.0002561547,0.3205133,0.00008925576,0.0002170578,0.004855633,0.001235677,0.001682511,0.6486712,0.0009212317,0.0001268032,0.02037507],"study_design_scores_gemma":[0.00006906414,0.0005484129,0.9702995,0.0000188757,0.0001048383,0.006790604,0.0004726551,0.002158999,0.01749725,0.00030451,0.001705683,0.00002966392],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996667,0.00007313708,0.0000667019,0.000005082175,0.00000104676,0.000003299782,0.00003197245,0.000003058521,0.0001489951],"genre_scores_gemma":[0.9993374,0.00009463059,0.0001180684,0.000009632328,0.000004732103,0.000003701148,0.0002096526,0.000004553046,0.0002176179],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001153323,"threshold_uncertainty_score":0.00378865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02896178004604647,"score_gpt":0.3031949768871746,"score_spread":0.2742331968411281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}