{"id":"W2118544138","doi":"10.1101/gr.2946205","title":"Gene conversion and evolution of Xq28 duplicons involved in recurring inversions causing severe hemophilia A","year":2005,"lang":"en","type":"article","venue":"Genome Research","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Thomas Hospital","funders":"Medical Research Council; Hospital for Sick Children; King's College London","keywords":"Gene conversion; Biology; Xq28; Genetics; Gene; Haplotype; Concerted evolution; Breakpoint; Molecular evolution; Non-allelic homologous recombination; X chromosome; Recombination; Chromosomal inversion; Chromosome; Sequence (biology); Gene duplication; Phylogenetics; Karyotype; Allele; Genetic recombination","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000591846,0.00008738563,0.000114441,0.0002688502,0.000110618,0.00001102257,0.00008672688,0.0001753453,0.00001968943],"category_scores_gemma":[0.0000762278,0.00009976566,0.0000348195,0.0003656132,0.0001465663,0.00001001323,0.0002395901,0.0001813214,0.0000072313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002844216,"about_ca_system_score_gemma":0.00020694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002398705,"about_ca_topic_score_gemma":0.0005522172,"domain_scores_codex":[0.998852,0.000118346,0.0001937264,0.0003153615,0.0002235187,0.0002970408],"domain_scores_gemma":[0.9993743,0.00002109718,0.00004735001,0.0002569926,0.0002119826,0.00008822524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001000936,0.0000313229,0.007711593,0.00004204668,0.0000171479,0.000001513038,0.0001437498,0.002681921,0.9875905,0.00002675677,0.0002294853,0.001423858],"study_design_scores_gemma":[0.003829295,0.0005569702,0.1105366,0.0002053696,0.00002801787,0.00007674069,0.00119592,0.0116094,0.8537347,0.0003032224,0.017354,0.0005697441],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960144,0.002838608,0.0001054234,0.0004305999,0.000033023,0.0002817204,0.0000129556,0.000005549982,0.0002777014],"genre_scores_gemma":[0.9982761,0.0006771014,0.0004978484,0.00001460038,0.0001336169,0.00001008614,0.00006389738,0.00001414147,0.0003126067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1338558,"threshold_uncertainty_score":0.4068325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02896178004604647,"score_gpt":0.3031949768871746,"score_spread":0.2742331968411281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}