{"id":"W2118572533","doi":"10.1093/hmg/ddr099","title":"Maternal germline-specific effect of DNA ligase I on CTG/CAG instability","year":2011,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; SickKids Foundation; Hospital for Sick Children","funders":"Canadian Institutes of Health Research","keywords":"Biology; Okazaki fragments; DNA replication; Germline; Somatic cell; Genetics; Trinucleotide repeat expansion; Myotonic dystrophy; Germline mosaicism; Molecular biology; DNA; Allele; Eukaryotic DNA replication; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001911803,0.000441513,0.0002231749,0.0003335553,0.0001105949,0.0002786174,0.0002510999,0.0003027011,0.002576786],"category_scores_gemma":[0.0003013527,0.0002028678,0.0001902552,0.0001199722,0.0003107014,0.00009584853,0.0003050661,0.0006356197,0.0003948275],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003913504,"about_ca_system_score_gemma":0.0002991374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001128499,"about_ca_topic_score_gemma":0.001701197,"domain_scores_codex":[0.9997168,0.00005639136,0.00002551808,0.00009130014,0.00005535099,0.00005470159],"domain_scores_gemma":[0.99946,0.000128615,0.0001743646,0.00006572683,0.00002564168,0.0001457196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008314216,0.00001550841,0.0003157059,0.0000146469,0.000004603167,0.00006098743,0.00001039942,0.00002498381,0.9986933,0.00008845526,0.00001716156,0.0006712173],"study_design_scores_gemma":[0.00001411816,0.0002830811,0.005739903,0.000008157373,0.00002231005,0.0003788769,0.0000191232,0.000529708,0.9913881,0.0000317933,0.001579916,0.000004971426],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934861,0.0009351919,0.002494702,0.0001203931,0.00003645438,0.00002655904,0.0005799721,0.0001295545,0.002191173],"genre_scores_gemma":[0.9946591,0.0004100721,0.0009637637,0.00004801863,0.000008697467,0.00001701758,0.0004141956,0.00006322485,0.003415956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002576786,"threshold_uncertainty_score":0.008620262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04684968859316172,"score_gpt":0.2748002221979831,"score_spread":0.2279505336048213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}