{"id":"W2118596628","doi":"10.7554/elife.06327","title":"Palmitoylation of LIM Kinase-1 ensures spine-specific actin polymerization and morphological plasticity","year":2015,"lang":"en","type":"article","venue":"eLife","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Heart and Stroke Foundation; University of Ottawa","funders":"National Institute of Neurological Disorders and Stroke; Shriners Hospitals for Children","keywords":"Cell biology; Dendritic spine; Cofilin; Actin remodeling; Palmitoylation; Actin cytoskeleton; Actin remodeling of neurons; Biology; Actin; MDia1; Cytoskeleton; Neuroscience; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002401372,0.0002460622,0.0002773294,0.0002134943,0.0003462972,0.0004041624,0.0003650612,0.0002933804,0.001223446],"category_scores_gemma":[0.0003445773,0.0002220839,0.000246131,0.0001657736,0.000425496,0.0003398168,0.0006293809,0.000472195,0.000828869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005630739,"about_ca_system_score_gemma":0.0003996817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004879459,"about_ca_topic_score_gemma":0.0009708868,"domain_scores_codex":[0.9997801,0.00002933262,0.00002646073,0.00005110624,0.00004440805,0.00006851056],"domain_scores_gemma":[0.9998038,0.00002432513,0.00006429946,0.00004164409,0.00002252329,0.00004350052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000149836,0.00001615555,0.0003155949,0.0000323679,0.000005335794,0.00003020426,0.000011516,0.0001285201,0.9976343,0.0002093171,0.00004162178,0.001425284],"study_design_scores_gemma":[0.00001085596,0.00004305257,0.002050398,0.000003072148,0.000009440509,0.0001161397,0.00001480673,0.0006675014,0.9954544,0.000122893,0.001503246,0.00000415934],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931101,0.000686759,0.004148308,0.0001403816,0.00001909961,0.00001883579,0.0002615638,0.0001459113,0.001469182],"genre_scores_gemma":[0.9962398,0.0003383545,0.001713639,0.00003528863,0.000004765115,0.00001761425,0.0002663232,0.00004538277,0.001338813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001223446,"threshold_uncertainty_score":0.004092813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02748776101492361,"score_gpt":0.2542984865680751,"score_spread":0.2268107255531515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}